Journal ArticleDOI
Colonoscopic surveillance in long-standing total ulcerative colitis—A 15-year follow-up study
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TLDR
The long-term use of colonoscopic surveillance in ulcerative colitis is a reliable way to select patients, in whom dysplasia is developing, for prophylactic surgery, and flow cytometric DNA analyses may help in the selection.About:
This article is published in Gastroenterology.The article was published on 1990-10-01. It has received 181 citations till now. The article focuses on the topics: Dysplasia & Ulcerative colitis.read more
Citations
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The risk of colorectal cancer in ulcerative colitis: a meta-analysis
TL;DR: Using new meta-analysis techniques, the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children was determined and how risk varies with geography was estimated.
Journal ArticleDOI
Cancer as an evolutionary and ecological process.
TL;DR: The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.
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Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.
Fernando Magro,Paolo Gionchetti,Rami Eliakim,Sandro Ardizzone,Alessandro Armuzzi,Manuel Barreiro-de Acosta,Johan Burisch,Krisztina Gecse,Ailsa Hart,Pieter Hindryckx,Cord Langner,Jimmy K. Limdi,Gianluca Pellino,Edyta Zagórowicz,Tim Raine,Marcus Harbord,Florian Rieder +16 more
TL;DR: This research presents a meta-analyses of Gastroenterology and Hepatology at the cellular and molecular level, which shows clear trends in the development of immune-oncology-metabolical pathways towards “clinically checkpoints”.
Journal ArticleDOI
Cancer risk in patients with inflammatory bowel disease: a population-based study.
TL;DR: The objective of the current study was to determine the incidence of cancer among persons with inflammatory bowel disease (IBD) and to compare these incidence rates with those of the non‐IBD population using population‐based data from the administrative claims data of Manitoba's universal provincial insurance plan (Manitoba Health).
Journal ArticleDOI
Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis
TL;DR: Patients should be informed about the limitations of colonoscopic surveillance so that they can take part rationally in decision-making about their management, and be aware of the risk of progression to dysplasia.
References
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Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
Journal ArticleDOI
Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
Robert H. Riddell,Harvey Goldman,David F. Ransohoff,Henry D. Appelman,Cecilia M. Fenoglio,Rodger C. Haggitt,Christer hren,Pelayo Correa,Stanley R. Hamilton,B C Morson,Sheldon C. Sommers,John H. Yardley +11 more
TL;DR: A classification system for the epithelial changes that occur in ulcerative colitis was developed, which should be applicable to other forms of inflammatory bowel disease as well and makes use of standardized terminology, addresses specific problem areas, and offers practical solutions.
Journal ArticleDOI
Rectal biopsy as an aid to cancer control in ulcerative colitis.
B C Morson,L S Pang +1 more
TL;DR: The detection of epithelial changes suggestive of precancer or carcinoma in situ in rectal biopsies from patients with ulcerative colitis prompted an investigation into the incidence and extent of such changes in colectomy specimens removed for colitis with and without malignant change.
Journal ArticleDOI
Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.
TL;DR: In performing colonoscopy over a 4-yr period on 112 patients with long-standing ulcerative colitis, a dysplasia-associated lesion or mass (DALM) was found in 12, carrying a sufficiently high risk of cancer, thereby constituting a strong indication for colectomy.
Journal ArticleDOI
Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.
S. N. Gyde,P Prior,R N Allan,A Stevens,Derek P. Jewell,S. C. Truelove,Robert Löfberg,Olle Broström,Göran Hellers +8 more
TL;DR: It is suggested that extensive colitis patients have a genetic predisposition to colorectal cancer and that longstanding inflammation is not of primary importance in the initiation/promotion of cancer in this disease.