Combined ∆9-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats.
Nnamdi G. Nelson,Wen Xuan Law,Michael J. Weingarten,Lauren N. Carnevale,Aditi Das,Nu Chu Liang +5 more
TLDR
A novel model of voluntary alcohol and THC consumption is established for studying mechanisms underlying the consequences of adolescent onset co-use of the two drugs.Abstract:
Whereas co-use of alcohol and marijuana is prevalent in adolescents, the effects of such drug co-exposure on ingestive and cognitive behaviors remain largely unexplored. We hypothesized that co-exposure to alcohol and ∆9-tetrahydrocannabinol (THC), the main psychoactive constitute of marijuana, alters feeding behavior and cognition differently from either drug alone. Male rats received daily THC (3–20 mg/kg/day) or oil vehicle through subcutaneous injection or consumption of a cookie with access to saccharin or saccharin-sweetened alcohol during adolescence (P30–45). Barnes maze and sucrose preference tests were applied to assess spatial memory and behavioral flexibility and abstinence-related anhedonia, respectively. Subcutaneous THC did not affect alcohol intake but dose-dependently increased acute (3 h) chow intake and reduced weight gain. Moderate alcohol consumption reduced the acute hyperphagic effect of subcutaneous THC. By contrast, oral THC at a dose > 5 mg/kg robustly reduced alcohol intake without affecting 3-h chow intake. At this dose, some rats stopped consuming the THC-laced cookies. Furthermore, oral THC reduced weight gain, and co-exposure to alcohol alleviated this effect. Chronic subcutaneous, but not oral, THC reduced sucrose intake during abstinence. Neither treatment impaired cognitive behaviors in the Barnes maze. Moderate alcohol and THC consumption can interact to elicit unique outcomes on ingestive behaviors and energy balance. Importantly, this study established a novel model of voluntary alcohol and THC consumption for studying mechanisms underlying the consequences of adolescent onset co-use of the two drugs.read more
Citations
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Exploring cannabis and alcohol co-use in adolescents: a narrative review of the evidence
TL;DR: Variation in study methodologies, policy-level limitations and limited understanding of the developmental neurobiological effects of cannabis preclude the straightforward interpretation of the existing data on adolescent cannabis and alcohol use.
Journal ArticleDOI
Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats
Shahnaza Hamidullah,Claudia D. Lutelmowski,Samantha D. Creighton,Karling R. Luciani,Jude A. Frie,Boyer D. Winters,Jibran Y. Khokhar +6 more
TL;DR: The results show that although adolescent THC exposure acutely affects alcohol drinking, adolescent alcohol and cannabis co-use may not produce long-term additive effects.
Journal ArticleDOI
Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice
TL;DR: This article developed a model of self-administration of Δ9-tetrahydrocannabinol (THC) and assessed its impact on CB1 receptor-mediated behaviors in female and male mice.
Journal ArticleDOI
Translational models of cannabinoid vapor exposure in laboratory animals.
TL;DR: This review examines the emerging field of preclinical vapor models with a focus on cannabinoid exposure to discuss the pharmacological and behavioral effects produced by exposure to vaporized cannabinoids, and compare behavioral effects of cannabinoid vapor administration with those of other routes of administration.
Journal ArticleDOI
Deleterious Effects of Ethanol, Δ(9)-Tetrahydrocannabinol (THC), and Their Combination on the Spatial Memory and Cognitive Flexibility in Adolescent and Adult Male Rats in the Barnes Maze Task.
TL;DR: Results show that there was a significant age effect on spatial memory in the Barnes maze task after these drug administrations, and in adult rats that received these drugs in adolescence, memory decline was observed only after ethanol and ethanol + THC administration.
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