Patent
Compositions and methods for regulating thermogenesis and muscle inflammation using metrnl and metrn
TLDR
In this paper, compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and or expression are provided. But none of these methods are suitable for treating metabolic disorders.Abstract:
The invention provides compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and/or expression. Also provided are methods for preventing or treating metabolic disorders and muscle inflammation disorders in a subject through modulation of Metrnl and/or Metrn activity and/or expression. Further provided are methods for identifying compounds that are capable of treating metabolic disorders and muscle inflammation disorders by modulating Metrnl and/or Metrn activity and/or expression.read more
Citations
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Patent
Application of metrnl protein in preparing hypolipidemic, hypoglycemic medicine
Miao Chaoyu,Li Zhiyong,Pei Wang +2 more
TL;DR: In this paper, the authors presented an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement, and they further provided a method for preparing a mouse with fat-specific overexpression of metrnl.
Patent
Methods of reducing blood glucose or triglyceride levels by administration of METRNL protein
Miao Chaoyu,Li Zhiyong,Pei Wang +2 more
TL;DR: In this article, the authors presented an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement, and they further provided a method for preparing a mouse with fat-specific overexpression of metrnl.
Patent
Rekombinante Herstellung von Subfatin
TL;DR: Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von Subfatin (meteorin-like protein/Metrnl) in einer Pflanzenzelle oder Hefezelle as mentioned in this paper.
Patent
Applications of Metrn1 protein or gene in regulation of expression of antibacterial peptides
Miao Chaoyu,Li Zhiyong +1 more
TL;DR: In this article, the high expression of Metrn1 protein or gene in human and mouse gastrointestinal tissues is displayed by using immunohistochemistry and quantitative PCR, and a Metrnl intestinal epithelial cell specific knockout mouse model is firstly established, and based on the model, the Metrn 1 deficiency in intestinal epithelium cells can cause the down-regulation of the expression of intestinal antibacterial peptides, such that theMetrn1 proteins or gene andthe synergist thereof can be used for preparing reagents for treatment or improvement of antibacterial deficiency or unbal
Patent
Composition for preventing or treating cancer containing metrnl (meteorin-like)
TL;DR: In this article, a pharmaceutical composition comprising a meteorin-like as an active component for preventing or treating cancer and inducing cell death and controlling cell proliferation of breast cancer cells, intestine cancer cells or cervical cancer cells was presented.
References
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Journal ArticleDOI
Basics and recent advances in peptide and protein drug delivery.
TL;DR: Oral and transdermal peptide drug delivery is discussed, focusing on barriers and solutions to absorption and stability issues, and methods to increase systemic stability and site-specific delivery are also discussed.
Book ChapterDOI
Targeted Gene Delivery: Importance of Administration Routes
TL;DR: The first clinical trial was performed for adenosine deaminase deficiency in 1990 and numerous clinical trials were carried out for other congenital genetic defects such as familial hypercholesterolemia and cystic fibrosis.
Journal ArticleDOI
Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools
Mirana Ramialison,Baubak Bajoghli,Baubak Bajoghli,Narges Aghaallaei,Narges Aghaallaei,Laurence Ettwiller,Sylvain Gaudan,Beate Wittbrodt,Thomas Czerny,Joachim Wittbrodt +9 more
TL;DR: This study provides evidence supported by experimental validation in medaka fish that brain 2 (POU domain, class 3, transcription factor 2), claudin-7, secretory pathway component sec31-like and meteorin-like precursor are novel direct downstream targets of PAX2/5/8.
Patent
Therapeutic use of a growth factor, METRNL
Jesper Roland Jørgensen,Lone Fjord-Larsen,Lars Wahlberg,Nuno Miguel Gomes Andrade,Teit E. Johansen +4 more
TL;DR: The METRNL as discussed by the authors is a Nerve Survival and Growth Factor with neuroprotective and/or neurogenesis effects, which is a secreted therapeutic protein for the treatment of disorders of the nervous system.
Patent
New polypeptides and peptides, nucleic acids coding for them, and their use in the field of tumor therapy, inflammation or immunology
TL;DR: In this paper, a polypeptide containing in its peptidic chain the amino acid sequence of 311 amino acids of figure 3, or a fragment of this sequence, with said fragment being such that it is liable to produce antibodies capable of forming a complex with the amino acids sequence of Figure 3, and an amino acid sequences having a percentage of homology of at least 50 %, preferably 75 %, and advantageously 90 % with Figure 3.