Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicans.
Mathias L. Richard,Armêl Plaine +1 more
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There are two types of membrane proteins: the integral membrane proteins and the lipid-anchored proteins, which are composed only of the proteins that contain a C-terminal signal sequence that allows for linkage to a glycosylphosphatidylinositol (GPI) anchor.Abstract:
There are two types of membrane proteins: the integral membrane proteins and the lipid-anchored proteins. Integral membrane proteins contain one or several transmembrane domains that allow for the formation of hydrophobic α-helices, which ultimately embed the protein in a lipid bilayer. We countread more
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Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance.
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Genetic and phenotypic intra-species variation in Candida albicans
Matthew P. Hirakawa,Diego Martinez,Sharadha Sakthikumar,Matthew Z. Anderson,Matthew Z. Anderson,Aaron M. Berlin,Sharvari Gujja,Qiandong Zeng,Ethan Zisson,Joshua M. Wang,Joshua M. Greenberg,Judith Berman,Judith Berman,Richard J. Bennett,Christina A. Cuomo +14 more
TL;DR: In this paper, extensive genomic and phenotypic analyses were performed on 21 clinical C. albicans isolates, revealing a natural mutation that alters the balance between commensalism and pathogenicity.
References
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Intragenic tandem repeats generate functional variability.
TL;DR: It is proposed that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system.
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The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research
TL;DR: Apart from providing stable membrane anchorage, GPI anchors have been implicated in the sequestration of GPI-anchored proteins into specialised membrane microdomains, known as lipid rafts, and in signal transduction events.
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Adhesive and Mammalian Transglutaminase Substrate Properties of Candida albicans Hwp1
TL;DR: A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases, representing a paradigm for microbial adhesion that implicates essential host enzymes.
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The ALS gene family of Candida albicans
TL;DR: The ALS genes are one example of a gene family associated with pathogenicity mechanisms in C. albicans and other Candida species and results in a diverse cell-surface Als protein profile that is also affected by growth conditions.
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Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo.
Clarissa J. Nobile,David R. Andes,Jeniel E. Nett,Frank J. Smith,Fu Yue,Quynh T. Phan,John E. Edwards,John E. Edwards,Scott G. Filler,Scott G. Filler,Aaron P. Mitchell +10 more
TL;DR: It is shown that an als3/als3 mutant is biofilm-defective in vitro, and that ALS3 overexpression rescues the biofilm defect of the bcr1/bcr1 mutant.