Journal ArticleDOI
Comprehensive multidimensional liquid chromatography: theory and applications
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TLDR
Comprehensive two-dimensional (2D) liquid chromatographic (LC x LC) techniques can be considered innovative methods only recently developed and adopted in many configurations, offering a high peak capacity to resolve samples of great complexity.About:
This article is published in Journal of Chromatography A.The article was published on 2008-03-14. It has received 310 citations till now. The article focuses on the topics: Two-dimensional chromatography.read more
Citations
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The multi-scale challenges of biomass fast pyrolysis and bio-oil upgrading: Review of the state of art and future research directions
Mahdi Sharifzadeh,Mahdi Sharifzadeh,Majid Sadeqzadeh,Miao Guo,Tohid N. Borhani,N. V. S. N. Murthy Konda,Marti Cortada Garcia,Lei Wang,Jason P. Hallett,Nilay Shah +9 more
TL;DR: In this paper, a comprehensive multi-scale review of the state of the art in fast pyrolysis is presented, as well as their multiscale interactions, including the reaction mechanisms and kinetics.
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Recent developments in liquid chromatography-mass spectrometry and related techniques.
TL;DR: This review summarizes the state-of-art in liquid chromatography-mass spectrometry (LC-MS) and related techniques with the main focus on recent developments in the last decade.
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New trends in fast and high-resolution liquid chromatography: a critical comparison of existing approaches.
TL;DR: This study demonstrates that the best analytical strategy should be selected on the basis of the analytical problem (e.g., isocratic vs. gradient, throughput vs. efficiency) and the properties of the analyte.
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Comprehensive liquid chromatography: fundamental aspects and practical considerations--a review.
TL;DR: The theoretical aspects of LC x LC are discussed together with practical considerations forLC x LC method development, and an extensive overview of different interface designs discussing their pros and cons is presented.
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Recent Developments in Two-Dimensional Liquid Chromatography: Fundamental Improvements for Practical Applications.
TL;DR: There simply is not enough room in LC chromatograms to separate very many compounds that behave "statistically" and the attainable peak capacity does not suffice to separate complex samples, so LC cannot easily deal with complex mixtures that contain more than a few dozen analytes.
References
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An Automated Multidimensional Protein Identification Technology for Shotgun Proteomics
TL;DR: An automated method for shotgun proteomics named MudPIT, which combines multidimensional liquid chromatography with electrospray ionization tandem mass spectrometry, improves the overall analysis of proteomes by identifying proteins of all functional and physical classes.
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Statistical theory of component overlap in multicomponent chromatograms
Joe M. Davis,J. Calvin Giddings +1 more
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Monolithic silica columns for high-efficiency chromatographic separations
Nobuo Tanaka,Hiroshi Kobayashi,Norio Ishizuka,Hiroyoshi Minakuchi,Kazuki Nakanishi,Ken Hosoya,Tohru Ikegami +6 more
TL;DR: Monolithic silica columns prepared from tetraalkoxysilane by a sol-gel method showed high efficiency and high permeability on the basis of the small-sized silica skeletons, large-sized through-pores, and resultingThrough-pore size/skeleton size ratios much larger than those found in a particle-packed column.
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Effect of Sampling Rate on Resolution in Comprehensive Two-Dimensional Liquid Chromatography
TL;DR: This paper studies the theoretical and experimental aspects of this sampling process of “comprehensive” two-dimensional liquid chromatography, where the column effluent from the first separation system is sequentially sampled by the second dimension separation system.