Fast, comprehensive two-dimensional liquid chromatography.
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TLDR
This report is deliberately focused on the issues involved in doing fast 2DLC by means of elevating the column temperature; however, many issues of broader applicability will be discussed.About:
This article is published in Journal of Chromatography A.The article was published on 2007-10-19 and is currently open access. It has received 384 citations till now. The article focuses on the topics: Two-dimensional chromatography.read more
Citations
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Journal ArticleDOI
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research
Augustin Scalbert,Lorraine Brennan,Oliver Fiehn,Thomas Hankemeier,Bruce S. Kristal,Bruce S. Kristal,Ben van Ommen,Estelle Pujos-Guillot,Elwin Verheij,David S. Wishart,Suzan Wopereis +10 more
TL;DR: The main obstacles limiting progress are reviewed and recommendations are made to improve the mode of collection and preparation of biological samples, the coverage and quality of mass spectrometry analyses, the extraction and exploitation of the raw data, the identification of the metabolites and the biological interpretation of the results.
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Core–shell particles: Preparation, fundamentals and applications in high performance liquid chromatography
TL;DR: This review shows the types of core-shell particles and how they are generally prepared, focusing on the methods used to produce core- Shell silica particles for chromatographic applications, and the use of columns packed with core- shell particles in different types of liquid chromatography.
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Effect-directed analysis supporting monitoring of aquatic environments - An in-depth overview
Werner Brack,Selim Ait-Aissa,Robert M. Burgess,Wibke Busch,Nicolas Creusot,Carolina Di Paolo,Beate I. Escher,L. Mark Hewitt,Klára Hilscherová,Juliane Hollender,Henner Hollert,Willem Jonker,Jeroen Kool,Marja H. Lamoree,Matthias Muschket,Steffen Neumann,Pawel Rostkowski,Christoph Ruttkies,Jennifer E. Schollée,Emma L. Schymanski,Tobias Schulze,Thomas-Benjamin Seiler,Andrew J. Tindall,Gisela de Aragão Umbuzeiro,Branislav Vrana,Martin Krauss +25 more
TL;DR: Current experience with the EDA approach and the tools required are summarized, and practical advice on their application is provided, highlighting the need for proper problem formulation and giving general advice for study design.
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Chromatographic separation techniques and data handling methods for herbal fingerprints: a review.
TL;DR: The evolution of the regulations and guidelines on the quality control of herbal medicines is considered, and the established analytical techniques for herbal fingerprinting are reviewed with an emphasis on the most recent developments, such as miniaturized techniques, new stationary phases, analysis at high temperatures and multi-dimensional chromatography.
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Implementations of two-dimensional liquid chromatography.
Georges Guiochon,Nicola Marchetti,Nicola Marchetti,Khaled S. Mriziq,Khaled S. Mriziq,R. Andrew Shalliker +5 more
TL;DR: It is suggested that the combination LC(x)xLC(t) shows exceptional promise because it permits the simultaneous second-dimension separations of all the fractions separated in the first-dimension, thus providing remarkable time saving.
References
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Book
The Fourier Transform and Its Applications
TL;DR: In this paper, the authors provide a broad overview of Fourier Transform and its relation with the FFT and the Hartley Transform, as well as the Laplace Transform and the Laplacian Transform.
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The Fourier Transform and Its Applications
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An Automated Multidimensional Protein Identification Technology for Shotgun Proteomics
TL;DR: An automated method for shotgun proteomics named MudPIT, which combines multidimensional liquid chromatography with electrospray ionization tandem mass spectrometry, improves the overall analysis of proteomes by identifying proteins of all functional and physical classes.
Book ChapterDOI
[31] Affinity chromatography
TL;DR: Inherent advantages of this method of purification are the rapidity and ease of a potentially single-step procedure, the rapid separation of the protein to be purified from inhibitors and destructive contaminants, such as proteases, and protection from denaturation during purification by active site ligand-stabilization of protein tertiary structure.
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Solvophobic interactions in liquid chromatography with nonpolar stationary phases
TL;DR: In this article, the solvophobic theory of solvent interaction with non-polar stationary phases in liquid chromatography is examined on the basis of solvophobia theory and a detailed analysis of the effect of the solvent on this process yields an expression for the capacity factor with essentially no adjustable constants.