Journal ArticleDOI
Controlled trial of exchange-transfusion therapy in fulminant hepatitis
AllanG. Redeker,HarryS. Yamahiro +1 more
Reads0
Chats0
TLDR
The survival of patients with fulminant hepatitis and stage-IV coma who were randomly selected to receive whole-blood exchange transfusion was not increased when compared to those patients who were not exchanged.About:
This article is published in The Lancet.The article was published on 1973-01-06. It has received 134 citations till now. The article focuses on the topics: Fulminant hepatitis & Fulminant hepatic failure.read more
Citations
More filters
Journal ArticleDOI
Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial.
F. D. Watanabe,Claudy J.-P. Mullon,W. Hewitt,Nicholas Arkadopoulos,E. Kahaku,Susumu Eguchi,Theodore M. Khalili,Walid S. Arnaout,Christopher R. Shackleton,Jacek Rozga,Barry D. Solomon,Achilles A. Demetriou +11 more
TL;DR: A bioartificial liver to treat patients with severe liver failure until they can be either transplanted or recover spontaneously and the authors' clinical experience with the BAL has yielded encouraging results.
Journal ArticleDOI
Artificial and Bioartificial Support Systems for Acute and Acute-on-Chronic Liver Failure: A Systematic Review
TL;DR: It is suggested that artificial support systems reduce mortality in acute-on-chronic liver failure compared with standard medical therapy and bioartificial support systems did not appear to affect mortality in chronic liver failure.
Journal ArticleDOI
Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells
Jacek Rozga,Frederick Williams,Man-soo Ro,Daniel F. Neuzil,Todd D. Giorgio,Todd D. Giorgio,Gisela Backfisch,Albert D. Moscioni,Raymond M. Hakim,Achilles A. Demetriou +9 more
TL;DR: A reproducible large‐animal model of acute ischemic liver failure was developed and dogs with acute liver failure had significantly lower serum ammonia and lactate levels and significantly higher serum glucose levels than did control animals treated with a bioartificial liver system inoculated with microcarriers alone.
Journal ArticleDOI
Fulminant hepatic failure
David A. Sass,A. Obaid Shakil +1 more
TL;DR: It is hoped that rapid conceptual and technologic developments with respect to hybrid systems, hepatocyte transplantation, and xenografting will yield a safe and accessible tool for managing these critically ill patients.
Journal ArticleDOI
Charcoal haemoperfusion in the treatment of fulminant hepatic failure.
B. G. Gazzard,M. J. Weston,I. M. Murray-Lyon,H. Flax,C.O Record,Bernard Portmann,Peter G. Langley,E. H. Dunlop,P. J. Mellon,M.B Ward,Roger Williams +10 more
TL;DR: Twenty-two patients with fulminant hepatic failure who deteriorated to grade-IV coma despite full supportive therapy were treated by repeated periods of haemoperfusion through columns containing activated charcoal, and follow-up liver biopsies showed restitution of the normal lobular architecture.
References
More filters
Journal ArticleDOI
Treatment of hepatic coma by exchange blood transfusion.
TL;DR: The protean nature of the neurologic disturbances associated with liver failure and the absence of specific neuropathological findings suggest that "hepatic coma" is metabolic in origin.
Journal ArticleDOI
Acute hepatic necrosis with stupor or coma. An analysis of thirty-one patients.
Donald J. Ritt,Gregory Whelan,David J. Werner,Edwin H. Eigenbrodt,Steven Schenker,Burton Combes +5 more
Journal Article
The fulminant hepatic failure surveillance study. Brief review of the effects of presumed etiology and age of survival.
Journal ArticleDOI
Exchange Transfusion in the Treatment of Fulminating Hepatitis
Robert L. Berger,Rodney M. Liversage,Thomas C. Chalmers,James H. Graham,David M. McGoldrick,Frederick Stohlman +5 more
TL;DR: If the patient could be supported during the acute destructive phase until hepatic function returned, the chances for survival might be increased, and massive doses of steroids are almost always employed in patients with fulminating hepatitis.