Journal ArticleDOI
Copper(I)-Catalyzed Enyne Oxidation/Cyclopropanation: Divergent and Enantioselective Synthesis of Cyclopropanes.
TLDR
In this article, an efficient copper(I)-catalyzed enyne oxidation/cyclopropanation for the modular synthesis of cyclopropane derivatives is described, which represents the first non-noble metal-catalystzed enynes oxidation and compropanization by the in situ generated α-oxo copper carbenes.About:
This article is published in Organic Letters.The article was published on 2021-02-02. It has received 16 citations till now. The article focuses on the topics: Enyne & Cyclopropanation.read more
Citations
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Journal ArticleDOI
Cu(I)- and Au(I)-catalyzed regioselective oxidation of diynes: divergent synthesis of N-heterocycles
Wen-Bo Shen,Ting-Ting Zhang,Meng Zhang,Jing-Jing Wu,Xiao-Lei Jiang,Guang-Xin Ru,Guang-Qin Gao,Xiu-Hong Zhu +7 more
TL;DR: In this article, a catalytic-dependent cyclization of diynes with pyridine Noxides is achieved using an amide directing group, which can be selectively activated by copper and gold, thus leading to divergent synthesis of a range of pyrroles and dihydroindeno[1,2-c]pyrrol-3(2H)-ones.
Journal ArticleDOI
Gold-Catalyzed Nitrene Transfer from Benzofuroxans to N-Allylynamides: Synthesis of 3-Azabicyclo[3.1.0]hexanes.
TL;DR: In this paper, a cyclopropanation of gold α-imino carbene intermediates is suggested as a key step of the catalytic cycle, which is shown to be a useful synthetic platform with an easily modulated substitution pattern as illustrated by their postmodifications.
Journal ArticleDOI
Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams.
TL;DR: In this paper, an efficient gold-catalyzed oxidative cyclization of amide-alkynes was developed, where a series of functionalized γ-lactams are easily accessed by employing this strategy.
Journal ArticleDOI
Copper Catalyzed Dearomatization by Michael-Type Addition of Indolyl Ynones: Divergent Synthesis of Functionalized Spiroindoles and Cyclopenta[c]quinolin-3-ones
Wen-Bo Shen,Guang-Xin Ru,Mengke Zhang,Ting-Ting Zhang,Xiao-Lei Jiang,Guangqin Gao,Xiu-Hong Zhu,Shu Wang,Cai-ling Fan,Xiao Chuan Li +9 more
TL;DR: A novel copper-catalyzed multifunctionalization of alkyne-tethered indoles is described, allowing practical and efficient synthesis of a diverse array of valuable dihalogen-substituted spiroindoles containing tetrasubstituting alkenes.
Journal ArticleDOI
Highly Site-Selective Oxidative Cyclization of Ene-ynamides via Non-Noble-Metal Catalysis: Access to Functionalized Lactams.
Bo‐Han Zhu,Cang-Hai Shen,Min-Ling Nie,Fumin Zheng,Chengzhe Huang,Fan Chen,Long Li,Chao Yong Deng,Long Ye,Peng-Cheng Qian +9 more
TL;DR: An unprecedented non-noble-metal-catalyzed oxidation/cyclization of ene-ynamides is developed, allowing the synthesis of diversely functionalized lactams in moderate to good yields with excellent diastereoselectivities without the observation of typical cyclopropanation products.
References
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An overview of N-heterocyclic carbenes
TL;DR: A concise overview of N-heterocyclic carbenes in modern chemistry is provided, summarizing their general properties and uses and highlighting how these features are being exploited in a selection of pioneering recent studies.
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Stereoselective Cyclopropanation Reactions
TL;DR: This review will focus mainly on the new methods that have appeared in the literature since 1989 for stereoselective cyclopropanation reactions from olefins: the halomethylmetal-mediated cycloalkane reactions, the transition metal-catalyzed decomposition of diazo compounds, and the nucleophilic addition-ring closure sequence.
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Catalytic carbene insertion into C-H bonds.
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Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
Ruth Dorel,Antonio M. Echavarren +1 more
TL;DR: Gold(I) complexes selectively activate π-bonds of alkenes in complex molecular settings, which has been attributed to relativistic effects as discussed by the authors, and are the most effective catalysts for the electrophilic activation of alkynes under homogeneous conditions.
Journal ArticleDOI
Diazo compounds and N-tosylhydrazones: novel cross-coupling partners in transition-metal-catalyzed reactions.
Qing Xiao,Yan Zhang,Jianbo Wang +2 more
TL;DR: It is shown that Pd carbene migratory insertion plays a vital role in merging the elementary steps of Pd intermediates, leading to novel carbon-carbon bond formations and the generality of the diazo compounds as new cross-coupling partners in transition-metal-catalyzed coupling reactions.