Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Jian Cheng Tu,Bo Xiao,Scott Naisbitt,Scott Naisbitt,Joseph P. Yuan,Ronald S. Petralia,Paul Brakeman,Andrew Doan,Vinay K. Aakalu,Anthony Lanahan,Morgan Sheng,Morgan Sheng,Paul F. Worley +12 more
TLDR
It is reported that Shank proteins also bind to Homer, and Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors.About:
This article is published in Neuron.The article was published on 1999-07-01 and is currently open access. It has received 1027 citations till now. The article focuses on the topics: Postsynaptic density & HOMER1.read more
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Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
TL;DR: The major triggers that initiate and maintain central sensitization in healthy individuals in response to nociceptor input and in patients with inflammatory and neuropathic pain are reviewed, emphasizing the fundamental contribution and multiple mechanisms of synaptic plasticity caused by changes in the density, nature, and properties of ionotropic and metabotropic glutamate receptors.
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Long-Term Potentiation and Memory
TL;DR: Lynch et al. as mentioned in this paper identified the cellular and molecu... cellular and memory cells in neuroscience is one of the most significant challenges in neuroscience and identified the most important genes for long-term potentiation and memory.
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The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains
TL;DR: This review highlights the analysis of those protein‐protein interactions that involve proline residues, the biochemistry of proline, and current drug discovery efforts based on proline peptidomimetics.
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PDZ Domains and the Organization of Supramolecular Complexes
Morgan Sheng,Carlo Sala +1 more
TL;DR: PDZ domains are modular protein interaction domains that bind in a sequence-specific fashion to short C-terminal peptides or internal peptides that fold in a beta-finger.
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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
TL;DR: Proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain indicates the NRC also participates in human cognition.
References
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Neuronal calcium signaling
TL;DR: This work was supported by a grant from the European Commission BIOMED2 (BMH4-CT96-0656) and has been endorsed by the Food and Drug Administration (FDA) for use in clinical practice.
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Homer: a protein that selectively binds metabotropic glutamate receptors.
Paul Brakeman,Anthony Lanahan,Richard O'Brien,Katherine W. Roche,Carol A. Barnes,Richard L. Huganir,Paul F. Worley +6 more
TL;DR: A novel dendritic protein, Homer, is reported that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors, suggesting that Homer mediates a novel cellular mechanism that regulates glutamate signalling.
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Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases
TL;DR: Functional and biochemical evidence is presented that cell-surface clustering of Shaker-subfamily K+ channels is mediated by the PSD-95 family of membrane-associated putative guanylate kinases, and the ability of PDZ domains to function as independent modules for protein–protein interaction, and their presence in other junction-associated molecules suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization.
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Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
Scott Naisbitt,Eunjoon Kim,Jian Cheng Tu,Bo Xiao,Carlo Sala,Juli G. Valtschanoff,Richard J. Weinberg,Paul F. Worley,Morgan Sheng +8 more
TL;DR: A novel family of postsynaptic density proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP, and may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD- 95 complexes and coupling them to regulators of the actin cytoskeleton.
Journal ArticleDOI
Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors
Jian Cheng Tu,Bo Xiao,Joseph P. Yuan,Anthony Lanahan,Kathleen Leoffert,Min Li,David J. Linden,Paul F. Worley +7 more
TL;DR: This work presents evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R), and identifies a novel mechanism in calcium signaling and provides evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.