Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity.
De Lisa Fairweather,Noel R. Rose +1 more
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TLDR
A model of CVB3-induced myocarditis presented here allows dissection of the contribution of viral infection and xenobiotics on immune dysregulation and inflammation in the heart to represent a clear challenge for immunotoxicologists.About:
This article is published in Methods.The article was published on 2007-01-01 and is currently open access. It has received 170 citations till now. The article focuses on the topics: Myocarditis & Autoimmune heart disease.read more
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Sex Differences in Autoimmune Disease from a Pathological Perspective
TL;DR: This review discusses the distribution of autoimmune diseases based on sex and age, showing that autoimmune diseases progress from an acute pathology associated with an inflammatory immune response to a chronic pathologyassociated with fibrosis in both sexes.
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Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association.
Biykem Bozkurt,Monica Colvin,Jennifer L. Cook,Leslie T. Cooper,Anita Deswal,Gregg C. Fonarow,Gary S. Francis,Daniel J. Lenihan,Eldrin F. Lewis,Dennis M. McNamara,Elfriede Pahl,Ramachandran S. Vasan,Kumudha Ramasubbu,Kismet Rasmusson,Jeffrey A. Towbin,Clyde W. Yancy +15 more
TL;DR: The intent of this American Heart Association (AHA) scientific statement is to summarize the current understanding of dilated cardiomyopathies, with special emphasis on recent developments in diagnostic approaches and therapies for specific cardiologyopathies.
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Infections and autoimmunity--friends or foes?
TL;DR: This work summarizes current knowledge of the relationship between infection and autoimmunity, and states that in many cases, it is not a single infection but rather the 'burden of infections' from childhood that is responsible for the induction of autoIMmunity.
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Molecular biology and pathogenesis of viral myocarditis
TL;DR: Advances in genomics and proteomics, and in the use of informatics and biostatistics, are allowing unbiased initial evaluations that can be the basis for testable hypotheses about virus pathogenesis and new therapies.
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Alternatively activated macrophages in infection and autoimmunity.
TL;DR: Women may be at an increased risk of M2-mediated autoimmunity due to estrogen's ability to increase Th2 responses, and shifts in M2 populations correlate with increased IC deposition, fibrosis and chronic autoimmune pathology.
References
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Journal ArticleDOI
Global Burden of Cardiovascular Diseases Part I: General Considerations, the Epidemiologic Transition, Risk Factors, and Impact of Urbanization
TL;DR: An overview of the global burden of atherothrombotic cardiovascular disease is provided and overarching factors influencing variations in CVD by ethnicity and region and the influence of urbanization are described.
Journal ArticleDOI
Air Pollution and Cardiovascular Disease A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association
Robert D. Brook,Barry A. Franklin,Wayne E. Cascio,Yuling Hong,George Howard,Michael Lipsett,Russell V. Luepker,Murray A. Mittleman,Jonathan M. Samet,Sidney C. Smith,Ira B. Tager +10 more
TL;DR: The purpose of this statement is to provide healthcare professionals and regulatory agencies with a comprehensive review of the literature on air pollution and cardiovascular disease and practical recommendations for healthcare providers and their patients are outlined.
Journal ArticleDOI
Inflammation as a cardiovascular risk factor.
TL;DR: In randomized, controlled trials, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, in the form of statins, have been shown to provide effective therapy for lowering CRP, in conjunction with their lipid-lowering effects.
BookDOI
The Autoimmune Diseases
Noel R. Rose,Ian R. Mackay +1 more
TL;DR: The biological basis of disease at genetic, molecular, cellular, and epidemiologic levels is discussed and tissue-specific interventions to arrest or cure autoimmune disease are discussed.
Journal ArticleDOI
Androgens and cardiovascular disease.
TL;DR: The commonality of risk factor patterns and mechanisms suggests that the efficacy of antiatherogenic therapy is an important challenge with the potential to enhance men's motivation for prevention and treatment of cardiovascular diseases.