Cross-Immunity between Brucella melitensis and Mycobacterium tuberculosis. Intracellular Behavior of Brucella melitensis in Monocytes from Vaccinated Animals.
TLDR
The ability of the monocytes from specifically immunized rabbits to retard the growth of virulent Brucella was demonstrated, not as an all-or-none phenomenon, but in the light of the unrestricted bacterial multiplication which occurs in monocyte from normal animals.Abstract:
A non-specific element has been demonstrated in the resistance of monocytes derived from immunized rabbits. Vaccination by BCG or by an effective anti-brucellosis reagent induces protection in either case against both Mycobacterium tuberculosis and Brucella melitensis when studied by the monocyte culture method.
The activity of the antiserum required to demonstrate the resistance of the monocyte is not affected when the agglutinating action of the anti- Brucella rabbit serum is removed by absorption.
The ability of the monocytes from specifically immunized rabbits to retard the growth of virulent Brucella was demonstrated, not as an all-or-none phenomenon, but in the light of the unrestricted bacterial multiplication which occurs in monocytes from normal animals.read more
Citations
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Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection.
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References
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TL;DR: The increased resistance to infection evoked in mice by lipopolysaccharides was effective against infections produced by endotoxin-bearing organisms-bacterial species highly susceptible in vitro to the bactericidal action of the properdin system.
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Studies on tubercle bacillus-monocyte relationship : i. quantitative analysis of effect of serum of animals vaccinated with bcg upon bacterium-monocyte system
TL;DR: Studies of the conditions necessary for maintenance of constant cell populations in vitro in the Mackaness type of culture chamber have indicated the importance of preliminary trypsinization of cells and the beneficial effect of 40 per cent rabbit serum in Tyrode's solution.