Journal ArticleDOI
The Role of Cell-Mediated Immunity in Bacterial Infections
TLDR
A study of Macrophage-Dependent Resistance in the Absence of Specific Immune Responses and the Role of Polymorphonuclear Leukocytes shows the importance of knowing the carrier and removal status of canine coronavirus.Abstract:
A. Macrophage-Dependent Resistance in the Absence of Specific Immune Responses.... 1223 B. Augmentation of Macrophage Numbers by Local Proliferation and Influx of Monocytes from the Blood 1223 C. Granuloma Formation 1224 D. Macrophage Activation 1224 E. The Genetic Basis of Mononuclear Phagocyte-Dependent Resistance ......... 1226 F. Role of Polymorphonuclear Leukocytes .... 1226read more
Citations
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Journal ArticleDOI
Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
TL;DR: Once inside a host cell, the infecting Listeria and their progeny can spread from cell to cell by remaining intracellular and thus bypass the humoral immune system of the organism.
Journal ArticleDOI
Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent
TL;DR: In this article, the authors identify the genes important for intracellular survival of Salmonella typhimurium and identify the mutants that have a diminished capacity for survival within macrophages.
Journal ArticleDOI
Role of hemolysin for the intracellular growth of Listeria monocytogenes.
TL;DR: Hemolytic-positive revertants were selected after passage of the hly- mutants through monolayers of J774 cells, and in each case, the hemolytic revertants possessed the 58-kD polypeptide, were capable of intracellular growth in tissue culture monolayer and were virulent for mice.
Journal ArticleDOI
Heat shock proteins and the immune response
TL;DR: The role of HSPs in immunity with respect to both their function and their antigenicity is discussed, among the most conserved molecules in phylogeny.
Journal ArticleDOI
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.
TL;DR: Assessment of the role of class I-restricted T cells in resistance to infection with virulent Mycobacterium tuberculosis in mice indicates that functional CD8 T cells, and possibly T cells bearing gamma delta antigen receptor, are a necessary component of a protective immune response to M. tuberculosis.
References
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Journal ArticleDOI
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution.
Ralph M. Steinman,Zanvil A. Cohn +1 more
TL;DR: Dendritic cells represent a novel cell type on both functional and morphological grounds and do not possess the functional properties of other types of reticular cells proposed to exist in lymphoid organs.
Journal ArticleDOI
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.
TL;DR: Evidence is presented here that the interaction of cytotoxic T cells with other somatic cells budding4–5 lymphocytic choriomeningitis (LCM) virus is similarly restricted.
Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity
Barry R. Bloom,Boyce Bennett +1 more
TL;DR: The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied and elaborated into the medium a soluble material capable of inhibiting migration of normal exudates.
Journal ArticleDOI
Cellular resistance to infection.
TL;DR: The mouse was found to be natively susceptible to Listeria monocytogenes, and its susceptibility was attributed to the capacity of the organism to survive and multiplying in host macrophages, while Histological evidence suggested that acquired resistance was the result of a change occurring in the host's mononuclear phagocytes.