Cross-roads in the classification of papillomaviruses
TLDR
The bumpy road towards achieving a classification system combined with the controversies of implementing and accepting new techniques will be summarized.About:
This article is published in Virology.The article was published on 2013-10-01 and is currently open access. It has received 407 citations till now.read more
Citations
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Journal ArticleDOI
Human papillomavirus molecular biology and disease association
TL;DR: Most work to date has focused on the study of high‐risk HPV types such as HPV 16 and 18, which has led to an understanding of the molecular pathways subverted by these viruses, which will lead to better strategies for disease treatment, including targeted antivirals and immunotherapeutics.
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Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia
TL;DR: It appears that cellular environment and the site of infection affect viral pathogenicity by modulating viral gene expression, and changes in E6 and E7 expression are thought to account for the development of neoplasias at the endocervix, the anal and cervical transformation zones, and the tonsilar crypts and other oropharyngeal sites.
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The human papillomavirus family and its role in carcinogenesis.
TL;DR: Additional research is necessary to characterize the biology and epidemiology of the vast number of HPV types that have been poorly investigated so far, with a final aim of clarifying their potential roles in other human diseases.
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The Papillomavirus Episteme: a major update to the papillomavirus sequence database.
Koenraad Van Doorslaer,Zhiwen Li,Sandhya Xirasagar,Piet Maes,David Kaminsky,David Liou,Qiang Sun,Ramandeep Kaur,Yentram Huyen,Alison A. McBride +9 more
TL;DR: The papillomavirus genomes within PaVE have been further annotated, and now includes the major spliced mRNA transcripts.
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The natural history of human papillomavirus infection.
TL;DR: Viral load and viral type are the main cofactors for progression from infection to cervical intraepithelial lesions and cancer and the adverse health effects of HPV infections can be largely controlled through vaccination and screening.
References
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Classification of papillomaviruses
Ethel Michele De Villiers,Claude M. Fauquet,Thomas R. Broker,Hans-Ulrich Bernard,Harald zur Hausen +4 more
TL;DR: The higher-order PV taxonomy is described following the general criteria established by the International Committee on the Taxonomy of Viruses (ICTV), reviews the literature of the lower order taxa, lists all known "PV types", and interprets their phylogenetic relationship.
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A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
TL;DR: The data indicate that HPV 16 DNA prevails in malignant tumors, rendering an accidental contamination with papillomavirus DNA from adjacent papillomas rather unlikely, and suggests a dependence of HPV 16 replication on helper virus.
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Classification of Papillomaviruses (PVs) Based on 189 PV Types and Proposal of Taxonomic Amendments
Hans-Ulrich Bernard,Robert D. Burk,Zigui Chen,Koenraad Van Doorslaer,Harald zur Hausen,Ethel Michele De Villiers +5 more
TL;DR: It is discussed that based on emerging species concepts derived from genome sequences, PV types could be promoted to the taxonomic level of species, but it is not recommended to implement this change at the current time.
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Papillomaviruses in the causation of human cancers — a brief historical account
TL;DR: This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments.
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A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.
TL;DR: DNA of a new papillomavirus type was cloned from a cervical carcinoma biopsy and the data reveal that the DNA might be integrated into the host cell genome, which is tentatively proposed to be HPV 18.