Papillomaviruses in the causation of human cancers — a brief historical account
TLDR
This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments.About:
This article is published in Virology.The article was published on 2009-02-20 and is currently open access. It has received 1288 citations till now. The article focuses on the topics: Cervical cancer.read more
Citations
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Cancer immunotherapy comes of age
TL;DR: In the context of advances in the understanding of how tolerance, immunity and immunosuppression regulate antitumour immune responses, these successes suggest that active immunotherapy represents a path to obtain a durable and long-lasting response in cancer patients.
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The biology and life-cycle of human papillomaviruses.
John Doorbar,Wim Quint,Lawrence Banks,Ignacio G. Bravo,Mark H. Stoler,Tom R. Broker,Margaret Stanley +6 more
TL;DR: The high-risk HPV types are a cause of several important human cancers, including almost all cases of cervical cancer, a large proportion of other anogenital cancers and a growing number of head and neck tumours.
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Approved Antiviral Drugs over the Past 50 Years
TL;DR: This paper presents for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide.
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Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis
Mohammad H. Forouzanfar,Kyle J Foreman,Allyne Delossantos,Rafael Lozano,Alan D. Lopez,Christopher J L Murray,Mohsen Naghavi +6 more
TL;DR: More policy attention is needed to strengthen established health-system responses to reduce breast and cervical cancer, especially in developing countries.
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Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona,Sofia Farkona,Eleftherios P. Diamandis,Eleftherios P. Diamandis,Eleftherios P. Diamandis,Ivan M. Blasutig,Ivan M. Blasutig,Ivan M. Blasutig +7 more
TL;DR: Some of the main strategies in cancer immunotherapy (cancer vaccines, adoptive cellular immunotherapy, immune checkpoint blockade, and oncolytic viruses) are outlined and the progress in the synergistic design of immune-targeting combination therapies is discussed.
References
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Clonal integration of a polyomavirus in human Merkel cell carcinoma.
TL;DR: In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.
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Case-control study of human papillomavirus and oropharyngeal cancer.
Aimée R. Kreimer,Raphael P. Viscidi,Michael Pawlita,Carole Fakhry,Wayne M. Koch,William H. Westra,Maura L. Gillison +6 more
TL;DR: Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
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Association of human papillomavirus types 16 and 18 E6 proteins with p53.
TL;DR: This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein, providing further evidence that the human papillomaviruses, the adenovirus type 5, and SV40 may effect similar cellular pathways in transformation.
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A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
TL;DR: The data indicate that HPV 16 DNA prevails in malignant tumors, rendering an accidental contamination with papillomavirus DNA from adjacent papillomas rather unlikely, and suggests a dependence of HPV 16 replication on helper virus.
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Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
Elisabeth Schwarz,U K Freese,Lutz Gissmann,Wolfgang Mayer,Birgit Roggenbuck,Armin Stremlau,Harald zur Hausen +6 more
TL;DR: It is found that the HPV 18 DNA is integrated into the cellular genome and is amplified in HeLa and 756 cells, and some of the transcripts are composed of HPV 18 and cellular sequences.