Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway
Laurence Serre,Alain Sailland,Denise Sy,Philippe Boudec,Anne Rolland,Eva Pebay-Peyroula,Claudine Cohen-Addad +6 more
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TLDR
Comparisons of the HPPD structure and its superposition with the structures of DHBD and MPC highlight some important differences in the active sites of these enzymes, which will aid the design of new inhibitors of the homogentisate biosynthesis reaction.About:
This article is published in Structure.The article was published on 1999-08-15 and is currently open access. It has received 138 citations till now. The article focuses on the topics: 4-Hydroxyphenylpyruvate dioxygenase & Homogentisate 1,2-dioxygenase.read more
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Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates.
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FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes.
TL;DR: The reactions catalyzed by this superfamily of enzymes are described, key active site features revealed by structural studies are highlighted, and results from spectroscopic and other approaches that provide insights into the chemical mechanisms are summarized.
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Genomic analysis of the aromatic catabolic pathways from Pseudomonas putida KT2440
TL;DR: The global view on the mineralization of aromatic compounds by P. putida KT2440 will facilitate the rational manipulation of this strain for improving biodegradation/biotransformation processes, and reveals this bacterium as a useful model system for studying biochemical, genetic, evolutionary and ecological aspects of the catabolism of aromatic compound.
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Mesotrione : a new selective herbicide for use in maize
Glynn Mitchell,David W Bartlett,Torquil Eoghan Macleod Fraser,Tim R. Hawkes,David C Holt,Jane Karen Townson,Rex A Wichert +6 more
TL;DR: Mesotrione is an extremely potent inhibitor of HPPD from Arabidopsis thaliana, with a Ki value of c 6-18 pM, which is rapidly taken up by weed species following foliar application, and is distributed within the plants by both acropetal and basipetal movement.
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The unique role of halogen substituents in the design of modern agrochemicals.
TL;DR: This review describes comprehensively the successful utilisation of halogens and their unique role in the design of modern agrochemicals, exemplified by various commercial products from Bayer CropScience coming from different agrochemical areas.
References
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PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
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The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
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Phase annealing in SHELX-90: direct methods for larger structures
TL;DR: In this article, a phase annealing method, related to the simulated-annealing approach in other optimization problems, is proposed and it is shown that it can result in an improvement of up to an order of magnitude in the chances of solving large structures at atomic resolution.
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Refinement of macromolecular structures by the maximum-likelihood method.
TL;DR: The likelihood function for macromolecular structures is extended to include prior phase information and experimental standard uncertainties and the results derived are consistently better than those obtained from least-squares refinement.
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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features
Wolfgang Kabsch,Chris Sander +1 more
TL;DR: A set of simple and physically motivated criteria for secondary structure, programmed as a pattern‐recognition process of hydrogen‐bonded and geometrical features extracted from x‐ray coordinates is developed.
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