Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial.
Yunes Panahi,Alireza Rahimnia,Mojtaba Sharafi,Gholam Hossein Alishiri,Amin Saburi,Amirhossein Sahebkar +5 more
TLDR
In patients with mild‐to‐moderate knee OA, curcuminoids represent an effective and safe alternative treatment for OA and there was no considerable adverse effect in both groups.Abstract:
Treatment of osteoarthritis (OA) is challenging owing to the inefficacy and long-term adverse events of currently available medications including non-steroidal anti-inflammatory drugs. Curcuminoids are polyphenolic phytochemicals with established anti-inflammatory properties and protective effects on chondrocytes. The aim of this study is to investigate the clinical efficacy of curcuminoids in patients suffering from knee OA. A pilot randomized double-blind placebo-control parallel-group clinical trial was conducted among patients with mild-to-moderate knee OA. Patients were assigned to curcuminoids (1500 mg/day in 3 divided doses; n = 19) or matched placebo (n = 21) for 6 weeks. Efficacy measures were changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS) and Lequesne's pain functional index (LPFI) scores during the study. There was no significant difference in age, gender, body mass index, and VAS, WOMAC and LPFI scores between the study groups at baseline (p > 0.05). Treatment with curcuminoids was associated with significantly greater reductions in WOMAC (p = 0.001), VAS (p 0.05). There was no considerable adverse effect in both groups. To conclude, curcuminoids represent an effective and safe alternative treatment for OA. Copyright © 2014 John Wiley & Sons, Ltd.read more
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Curcumin: A Review of Its Effects on Human Health.
Susan Hewlings,Douglas S. Kalman +1 more
TL;DR: The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits ofCurcumin combined with enhancing agents provides multiple health benefits.
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Validity and reliability.
TL;DR: Validity and reliability are two important characteristics of behavioral measure and are referred to as credibility and reliability.
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Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases
Ajaikumar B. Kunnumakkara,Devivasha Bordoloi,Ganesan Padmavathi,Javadi Monisha,Nand Kishor Roy,Sahdeo Prasad,Bharat B. Aggarwal +6 more
TL;DR: Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 by two German Scientists, Vogel and Pelletier.
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The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update.
TL;DR: An updated overview of the metabolism and mechanism of action ofCurcumin in various organ pathophysiologies is provided and the potential for multifunctional therapeutic application of curcumin is discussed and its recent progress in clinical biology is discussed.
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Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review
TL;DR: Turmeric and curcumin are nonmutagenic and are safe in pregnancy in animals but more studies in human are needed and there are still few trials and more studies are needed specially on nanoformulations.
References
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Journal Article
Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.
TL;DR: WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
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The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.
Roy D. Altman,Graciela S. Alarcón,D. Appelrouth,Daniel Bloch,David G. Borenstein,Kenneth D. Brandt,C. Brown,Cooke Td,W W Daniel,D. Feldman,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,Robert W. Ike,P. Kapila,David L. Kaplan,William J. Koopman,Catherine Marino,Eric V. McDonald,Dennis J. McShane,Thomas A. Medsger,B. A. Michel,William A. Murphy,T. Osial,Rosalind Ramsey-Goldman,Bruce M. Rothschild,Frederick Wolfe +26 more
TL;DR: Clinical criteria for the classification of symptomatic idiopathic (primary) osteoarthritis of the hands were developed from data collected in a multicenter study and required that at least 3 of these 4 criteria be present to classify a patient as having OA of the hand.
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A Controlled Study
TL;DR: I feel let down by the overstatement and it does not seem cricket to whet the reader's appetite by including in the title the come-on phrase "controlled study" when the method used is not really rigidly controlled.
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
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Antioxidant and radical scavenging properties of curcumin.
Tuba Ak,İlhami Gülçin +1 more
TL;DR: The antioxidant activity of curcumin was determined by employing various in vitro antioxidant assays such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH*) scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, N,N-dimethyl-p-phenylenediamine dihydrochloride