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Current protocols in nucleic acid chemistry
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The article was published on 1999-01-01 and is currently open access. It has received 545 citations till now. The article focuses on the topics: Nucleic acid methods.read more
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RNAstructure: software for RNA secondary structure prediction and analysis
TL;DR: New extensions to RNAstructure are described, including a library of C++ classes for incorporation into other programs, a user-friendly graphical user interface written in JAVA, and new Unix-style text interfaces that serve to make RNA secondary structure prediction user- friendly.
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Delivery materials for siRNA therapeutics
TL;DR: An introduction to the biological challenges that siRNA delivery materials aim to overcome is provided, as well as a discussion of the way that the most effective and clinically advanced classes of si RNA delivery systems are designed to surmount these challenges.
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Genome-wide measurement of RNA secondary structure in yeast
TL;DR: A novel strategy termed parallel analysis of RNA structure (PARS), which is based on deep sequencing fragments of RNAs that were treated with structure-specific enzymes, is described, thus providing simultaneous in vitro profiling of the secondary structure of thousands of RNA species at single nucleotide resolution.
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Chemical Strategies for Generating Protein Biochips
TL;DR: Different approaches using covalent and noncovalent chemistry are reviewed; particular emphasis is placed on the chemical specificity of protein attachment and on retention of protein function.
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Unbiased Whole-Genome Amplification Directly From Clinical Samples
Seiyu Hosono,A. Fawad Faruqi,Frank B. Dean,Yuefen Du,Zhenyu Sun,Xiaohong Wu,Jing Du,Stephen F. Kingsmore,Michael Egholm,Roger S. Lasken +9 more
TL;DR: Amplification of genomic DNA directly from cells is highly reproducible, eliminates the need for DNA template purification, and allows genetic testing from small clinical samples, compared with older, PCR-based methods.