Journal ArticleDOI
Current status and future potential of transdermal drug delivery
TLDR
The already significant impact this field has made on the administration of various pharmaceuticals is discussed; limitations of the current technology are explored; methods under exploration for overcoming these limitations and the challenges ahead are discussed.Abstract:
The past twenty five years have seen an explosion in the creation and discovery of new medicinal agents. Related innovations in drug delivery systems have not only enabled the successful implementation of many of these novel pharmaceuticals, but have also permitted the development of new medical treatments with existing drugs. The creation of transdermal delivery systems has been one of the most important of these innovations, offering a number of advantages over the oral route. In this article, we discuss the already significant impact this field has made on the administration of various pharmaceuticals; explore limitations of the current technology; and discuss methods under exploration for overcoming these limitations and the challenges ahead.read more
Citations
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Journal ArticleDOI
Transdermal drug delivery
Mark R. Prausnitz,Robert Langer +1 more
TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.
Journal ArticleDOI
Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
Journal ArticleDOI
Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
TL;DR: Results indicate that biodegradable polymer microneedles can be fabricated with an appropriate geometry and sufficient strength to insert into skin, and thereby dramatically increase transdermal transport of molecules.
Journal ArticleDOI
Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects.
Sutapa Barua,Samir Mitragotri +1 more
TL;DR: This review focuses on the current understanding of penetration of NPs through biological barriers, andphasis is placed on transport barriers and not immunological barriers.
Journal ArticleDOI
Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering
Brian G. Saar,Christian W. Freudiger,Jay Reichman,C. Michael Stanley,Gary R. Holtom,X. Sunney Xie +5 more
TL;DR: In vivo SRS imaging in living animals and humans is enabled by substantially enhancing the collection of the backscattered signal and increasing the imaging speed by three orders of magnitude to video rate, which allows label-free in vivo imaging of water, lipid, and protein in skin and mapping of penetration pathways of topically applied drugs in mice and humans.
References
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Journal ArticleDOI
Predicting skin permeability.
Russell O. Potts,Richard H. Guy +1 more
TL;DR: A facile interpretation of a considerable body of skin permeability measurements is presented that very adequately describes the dependence of Kp upon permeant size and lipophilicity, generates parameters of considerable physicochemical and mechanistic relevance, and implies that the SC lipids alone can fully characterize the barrier properties of mammalian skin.