Journal ArticleDOI
Current status of phthalocyanines in the photodynamic therapy of cancer
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TLDR
The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalcyanine induced apoptosis using a silicon phthalicyanine, Pc4, and a brief summary of the latest clinical results using phthalOCyanines is presented.Abstract:
Photodynamic therapy is a binary treatment now accepted in clinic for various malignancies in several countries around the world. Phthalocyanine molecules are second-generation photosensitizers with enhanced photophysical and photochemical properties over those of porphyrins. They have been shown to be phototoxic against a number of cell types and tumor models. A great deal of research has been devoted to the elucidation of their mechanism of action and mode of cell death. The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalocyanine induced apoptosis using a silicon phthalocyanine, Pc4. A brief summary of the latest clinical results using phthalocyanines is presented.read more
Citations
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The role of porphyrin chemistry in tumor imaging and photodynamic therapy
TL;DR: This critical review is focused on the basic concept of PDT, advantages of long-wavelength absorbing photosensitizers (PS), a brief discussion on recent advances in developing PDT agents, and the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo.
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The role of apoptosis in response to photodynamic therapy: what, where, why, and how
TL;DR: The purpose of this review is to critically evaluate all of the recently published research on PDT-induced apoptosis, with a focus on studies providing mechanistic insights.
Journal ArticleDOI
Photosensitizers in clinical PDT.
TL;DR: This review looks at the potential benefits and consequences of each major photosensitizer that has been tried in a clinical setting.
Journal ArticleDOI
Semiconductor quantum dots for photodynamic therapy.
TL;DR: The study revealed that the QDs could be used to sensitize the PDT agent through a fluorescence resonance energy transfer (FRET) mechanism, or interact directly with molecular oxygen via a triplet energy-transfer process (TET).
Journal ArticleDOI
Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer.
Yu Cheng,Anna Cristina S. Samia,Joseph D. Meyers,Irene Panagopoulos,Baowei Fei,Clemens Burda +5 more
TL;DR: A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action as discussed by the authors.
References
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Book
Photodynamic Therapy
TL;DR: A comprehensive review of mechanisms of subcellular and tumor localization of photosensitizing agents, as well as of molecular, cellular, and tumor responses associated with photodynamic therapy, are discussed.
Book
Phthalocyanines : properties and applications
TL;DR: In this paper, the most recent research on the fundamental and applied chemistry of the phthalocyanine derivatives is presented in a detailed and comprehensive way, including their redox character, essential to many of their potential industrial applications.
Journal ArticleDOI
Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy
Journal Article
Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor
TL;DR: The protective effect against photodynamic inactivation of the TA-3 cells afforded by 1,3-diphenylisobenzofuran coupled with the nearly quantitative formation of the singlet oxygen-trapping product indicates that Singlet oxygen is the probable agent responsible for toxicity in this system.
Journal ArticleDOI
Photophysical and photobiological processes in the photodynamic therapy of tumours
TL;DR: The purpose of this review article is to summarize the up-to-date knowledge on the mechanisms responsible for the induction of tumour necrotic reactions.