Journal ArticleDOI
Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets.
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TLDR
Cyclic AMP may play a crucial role in the regulation of platelet phospholipase acitivity, and this could explain at least in part the inhibition of aggregation caused by substances which, like prostacyclin, raise the levels of cyclicAMP.About:Â
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1977-06-06. It has received 192 citations till now. The article focuses on the topics: Prostacyclin & Platelet.read more
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Journal ArticleDOI
Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187
TL;DR: Production of thrombin at a site of vascular injury could, by stimulating PGI(2) synthesis by endothelial cells adjacent to the injured area, limit the number of platelets involved in the primary hemostatic response and help to localize thrombus formation.
Journal ArticleDOI
Effect of Heparin and Heparin Fractions on Platelet Aggregation
TL;DR: It is suggested that formation of an antithrombin-heparin complex protected platelets from aggregation by heparin and may improve anticoagulant therapy and development of thromboresistant heparIn-coated artificial materials.
Journal ArticleDOI
Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects.
Takashi Terano,Aizan Hirai,Tomohito Hamazaki,Satoru Kobayashi,Takao Fujita,Yasushi Tamura,Akira Kumagai +6 more
TL;DR: Reduction of platelet aggregation and improvement of the rheological properties of the erythrocyte might be explained by an increase in the EPA content in platelet and ery Throcyte phospholipids.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.