Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial.
Daniel C. Cattran,Gerald B. Appel,Lee A. Hebert,Lawrence G. Hunsicker,Marc A. Pohl,Wendy E. Hoy,Douglas R. Maxwell,Cheryl L. Kunis +7 more
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TLDR
This study suggests that cyclosporine is an effective therapeutic agent in the treatment of steroid-resistant cases of MGN, and 39% of the treated patients remained in remission and were subnephrotic for at least one-year post-treatment, with no adverse effect on filtration function.About:
This article is published in Kidney International.The article was published on 2001-04-01 and is currently open access. It has received 306 citations till now. The article focuses on the topics: Membranous nephropathy & Prednisolone.read more
Citations
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KDIGO Clinical Practice Guideline for Glomerulonephritis
TL;DR: This chapter discusses general principles in the management of glomerular disease, as well as methods for guideline development and examples of successful implementation of these principles.
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KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases
Brad H. Rovin,Sharon G. Adler,Jonathan Barratt,Frank Bridoux,Kelly A. Burdge,Tak Mao Chan,H. Terence Cook,Fernando C. Fervenza,Keisha L. Gibson,Richard J. Glassock,David Jayne,Vivekanand Jha,Adrian Liew,Zhihong Liu,Juan M. Mejia-Vilet,Carla M. Nester,Jai Radhakrishnan,Elizabeth M. Rave,Heather N. Reich,Pierre Ronco,Jan-Stephan F. Sanders,Sanjeev Sethi,Yusuke Suzuki,Sydney C.W. Tang,Vladimir Tesar,Marina Vivarelli,Jack F.M. Wetzels,Jürgen Floege +27 more
Journal ArticleDOI
The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines--application to the individual patient.
TL;DR: Vignettes are introduced within the context of the glomerulonephritis guideline cases with specific features to illustrate the constant need for clinical judgment and how the best treatment plans should be individualized and take into account patient preference and clinical acumen, as well as the best available evidence.
Journal ArticleDOI
Spontaneous Remission of Nephrotic Syndrome in Idiopathic Membranous Nephropathy
Natalia Polanco,E. Gutiérrez,Adelardo Covarsí,Francisco Ariza,A Carreño,Ana Vigil,José Baltar,Gema Fernández-Fresnedo,Carmen Martín,Salvador Pons,Dolores Lorenzo,Carmen Bernis,Pilar Arrizabalaga,Gema Fernández-Juárez,Vicente Barrio,Milagros Sierra,Ines Castellanos,Mario Espinosa,Francisco Rivera,Aniana Oliet,Francisco Fernández-Vega,Manuel Praga +21 more
TL;DR: Spontaneous remission is common among patients with nephrotic syndrome resulting from membranous nephropathy and carries a favorable long-term outcome with a low incidence of relapse.
Journal ArticleDOI
Proteinuria as a surrogate outcome in CKD: report of a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration.
Andrew S. Levey,Daniel C. Cattran,Aaron L. Friedman,W. Greg Miller,John R. Sedor,Katherine R. Tuttle,Bertram L. Kasiske,Thomas H. Hostetter +7 more
TL;DR: There appears to be sufficient evidence to recommend changes in proteinuria as a surrogate for kidney disease progression in only selected circumstances, and collaboration among many groups, including academia, industry, the FDA, and the National Institutes of Health are recommended to share data from past and future studies.
References
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Journal ArticleDOI
Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study.
Peterson Jc,Adler S,Burkart Jm,Tom Greene,Hebert La,Lawrence G. Hunsicker,King Aj,Klahr S,Massry Sg,Joseph Seifter +9 more
TL;DR: The MDRD Study compared the rates of decline in glomerular filtration rate in 840 patients with a diverse array of renal diseases who were randomly assigned to either a usual or a low blood pressure goal and evaluated the effect of blood pressure on changes in proteinuria.
Journal ArticleDOI
Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997.
TL;DR: The main findings of this study were that, during the 1976 to 1979 period, the relative frequencies of membranous and minimal-change nephropathies and of FSGS as causes of unexplained nephrotic syndrome were similar to those observed in previous studies during the 1970s and early 1980s.
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Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases.
Gilles Feutren,M. J. Mihatsch +1 more
TL;DR: The risk of nephropathy development in patients with autoimmune diseases who are treated with cyclosporine can be minimized by allowing a dose no higher than 5 mg per kilogram per day and avoiding increases in serum creatinine of more than 30 percent above the patient's base-line value.
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A Randomized Trial of Methylprednisolone and Chlorambucil in Idiopathic Membranous Nephropathy
Claudio Ponticelli,Pietro Zucchelli,Patrizia Passerini,Leonardo Cagnoli,Bruno Mario Cesana,Claudio Pozzi,Sonia Pasquali,Enrico Imbasciati,Claudio Grassi,Redaelli B,Mauro Sasdelli,Francesco Locatelli +11 more
TL;DR: It is concluded that steroid and chlorambucil treatment for six months favors remission of the nephrotic syndrome in adults with idiopathic membranous nephropathy and can preserve renal function for at least some years.
Journal ArticleDOI
A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy
Claudio Ponticelli,Pietro Zucchelli,Patrizia Passerini,Bruno Mario Cesana,Francesco Locatelli,Sonia Pasquali,Mauro Sasdelli,Redaelli B,Claudio Grassi,Claudio Pozzi,Daniela Bizzarri,Giovanni Banfi +11 more
TL;DR: A six-month therapy with methylprednisolone and chlorambucil increases the probability of remission of proteinuria and protects from renal function deterioration even in the long-term.
Related Papers (5)
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Claudio Ponticelli,Paolo Altieri,Francesco Scolari,Patrizia Passerini,Dario Roccatello,Bruno Mario Cesana,Patrizia Melis,B. Valzorio,Mauro Sasdelli,Sonia Pasquali,Claudio Pozzi,Giuseppe Piccoli,Antonio Lupo,Siro Segagni,F Antonucci,Mauro Dugo,Marilena Minari,Alfio Scalia,Luciano A. Pedrini,Gabriele Pisano,Claudio Grassi,Marco Farina,Roberto Bellazzi +22 more