J
John R. Sedor
Researcher at Case Western Reserve University
Publications - 165
Citations - 9189
John R. Sedor is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Kidney disease & Disease. The author has an hindex of 48, co-authored 155 publications receiving 8143 citations. Previous affiliations of John R. Sedor include Cleveland Clinic Lerner College of Medicine & MetroHealth.
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Journal ArticleDOI
MYH9 is associated with nondiabetic end-stage renal disease in African Americans
W. H. Linda Kao,Michael J. Klag,Lucy A. Meoni,David Reich,David Reich,Yvette Berthier-Schaad,Man Li,Josef Coresh,Nick Patterson,Arti Tandon,Arti Tandon,Neil R. Powe,Nancy E. Fink,John H. Sadler,Matthew R. Weir,Hanna E. Abboud,Sharon G. Adler,Jasmin Divers,Sudha K. Iyengar,Barry I. Freedman,Paul L. Kimmel,William C. Knowler,Orly F. Kohn,Kristopher Kramp,David J. Leehey,Susanne B. Nicholas,Madeleine V. Pahl,Jeffrey R. Schelling,John R. Sedor,Denyse Thornley-Brown,Cheryl A. Winkler,Michael W. Smith,Rulan S. Parekh +32 more
TL;DR: Multiple common SNPs in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic E SRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.
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Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.
Michael S. Simonson,Shianq Wann,P. Mene,George R. Dubyak,Mark Kester,Yuichi Nakazato,John R. Sedor,Michael J. Dunn +7 more
TL;DR: Endothelin at low concentrations (0.1-10 nM) induced mitogenesis by quiescent rat glomerular mesangial cells in culture and functions as a mitogen, presumably through activation of phospholipase C.
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EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt
Hui Miao,Da Qiang Li,Amitava Mukherjee,Hong Guo,Aaron Petty,Jennifer L. Cutter,James P. Basilion,John R. Sedor,Jiong Wu,David Danielpour,Andrew E. Sloan,Mark L. Cohen,Bingcheng Wang +12 more
TL;DR: In human astrocytoma, S897 phosphorylation was correlated with tumor grades and Akt activation, suggesting that the Akt-EphA2 crosstalk may contribute to brain tumor progression.
Journal ArticleDOI
Chronic Kidney Disease and Its Complications
TL;DR: A multidisciplinary approach is required to accomplish this goal of reducing morbidity and mortality in CKD patients with a number of serious complications.
Journal ArticleDOI
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
Hui Miao,Bih Rong Wei,Donna M. Peehl,Qing Li,Terry Alexandrou,Jeffrey R. Schelling,Johng S. Rhim,John R. Sedor,Elisabeth Burnett,Bingcheng Wang +9 more
TL;DR: This article showed that Eph receptor tyrosine kinases (RTKs) and membrane-anchored ephrin ligands critically regulate axon pathfinding and development of the cardiovascular system, as well as migration of neural cells.