Journal ArticleDOI
Cyst Fluid Carcinoembryonic Antigen Is an Accurate Diagnostic Marker of Pancreatic Mucinous Cysts
Sevdenur Cizginer,Brian G. Turner,A Reyyan Bilge,Cetin Karaca,Martha B. Pitman,William R. Brugge +5 more
TLDR
Cyst fluid CEA concentration provides a highly accurate test for the diagnosis of a mucinous cyst, but does not distinguish benign from malignant cysts.Abstract:
Objectives:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts.Methods:The resulread more
Citations
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International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Masao Tanaka,Carlos Fernandez-del Castillo,Volkan Adsay,Suresh T. Chari,Massimo Falconi,Jin-Young Jang,Wataru Kimura,Philippe Lévy,Martha B. Pitman,C. Max Schmidt,Michio Shimizu,Christopher L. Wolfgang,Koji Yamaguchi,Kenji Yamao +13 more
TL;DR: The present guidelines include recent information and recommendations based on the current understanding, and highlight issues that remain controversial and areas where further research is required.
Journal ArticleDOI
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Masao Tanaka,Carlos Fernandez-del Castillo,Terumi Kamisawa,Jin-Young Jang,Philippe Lévy,Takao Ohtsuka,Roberto Salvia,Yasuhiro Shimizu,Minoru Tada,Christopher L. Wolfgang +9 more
TL;DR: The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.
Journal ArticleDOI
European evidence-based guidelines on pancreatic cystic neoplasms
Marco Del Chiaro,Marc G. Besselink,Lianne Scholten,Marco J. Bruno,Djuna L. Cahen,Thomas M. Gress,Jeanin E. van Hooft,Markus M. Lerch,Julia Mayerle,Thilo Hackert,Sohei Satoi,Alessandro Zerbi,David Cunningham,Claudio De Angelis,Marc Giovanni,Enrique de-Madaria,Péter Hegyi,Jonas Rosendahl,Helmut Friess,Riccardo Manfredi,Philippe Lévy,Francisco X. Real,Alain Sauvanet,Mohammed Abu Hilal,Giovanni Marchegiani,Irene Esposito,Paula Ghaneh,Marc R. W. Engelbrecht,Paul Fockens,Nadine C.M. van Huijgevoort,Christopher L. Wolfgang,Claudio Bassi,Natalya Gubergrits,Caroline S. Verbeke,Günter Klöppel,Aldo Scarpa,Giuseppe Zamboni,Anne Marie Lennon,Malin Sund,Nikolaos Kartalis,Lars Grenacher,Massimo Falconi,Urban Arnelo,Kostantin V. Kopchak,Kofi Oppong,Colin J. McKay,Truls Hauge,Kevin C. Conlon,Mustapha Adham,Güralp O. Ceyhan,Roberto Salvia,Christos Dervenis,Peter J. Allen,François Paye,Detlef K. Bartsch,Matthias Löhr,Massimiliano Mutignani,Johanna Laukkarinen,Richard D. Schulick,Roberto Valente,Thomas Seufferlein,Gabriele Capurso,Ajith K. Siriwardena,John P. Neoptolemos,Aldis Pukitis,Ralf Segersvärd,Ali A. Aghdassi,Stefano Andrianello,Peter Bossuyt,Robin Bülow,Karina Cárdenas-Jaén,P. Cortegoso,Martina Fontana,Lena Haeberle,M. Heckler,Andrey Litvin,Kulbir Mann,Christoph W. Michalski,Patrick Michl,Gennaro Nappo,Giampaolo Perri,S. Persson,F. Scheufele,Francesco Sclafani,Manuel Schmidt,L. Venezia,F. Volker,M-P Vullierm,L. Wusten +88 more
TL;DR: A conservative approach is recommended for asymptomatic MCN and IPMN, and Lifelong follow-up of IPMN is recommended in patients who are fit for surgery.
Journal ArticleDOI
International cancer of the pancreas screening (CAPS) consortium summit on the management of patients with increased risk for familial pancreatic cancer
Marcia I. Canto,Femme Harinck,Ralph H. Hruban,G. J. A. Offerhaus,Jan Werner Poley,Ihab R. Kamel,Yung Nio,Richard S. Schulick,Claudio Bassi,Irma Kluijt,Michael J. Levy,Amitabh Chak,Paul Fockens,Michael Goggins,Marco J. Bruno +14 more
TL;DR: In this paper, a 49-expert multidisciplinary international consortium met to discuss pancreatic screening and vote on statements on screening, surveillance and management of high-risk individuals with an inherited predisposition to pancreatic cancer.
International Cancer of Pancreas Screening (CAPS) Consortium. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer.
Mi Canto,Femme Harinck,Rh Hruban,Gj Offerhaus,Jw Poley,Ihab R. Kamel,Yung Nio,Rs Schulick,Claudio Bassi,Irma Kluijt,Mj Levy,Amitabh Chak,Paul Fockens,M. Goggins,Miguel Bruno +14 more
TL;DR: Screening is recommended for high-risk individuals, but more evidence is needed, particularly for how to manage patients with detected lesions, particularly at high-volume centres with multidisciplinary teams.
References
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Journal ArticleDOI
Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study.
William R. Brugge,Kent B. Lewandrowski,Elizabeth Lee-Lewandrowski,Barbara A. Centeno,Tara E. Szydlo,Susan Regan,Carlos Fernandez-del Castillo,Andrew L. Warshaw +7 more
TL;DR: Of tested markers, cyst fluid CEA is the most accurate test available for the diagnosis of mucinous cystic lesions of the pancreas.
Journal ArticleDOI
Endosonography-guided fine-needle aspiration biopsy: Diagnostic accuracy and complication assessment
TL;DR: EUS-FNA accurately and safely evaluates solid peri-intestinal lesions and improves lymph node staging accuracy and specificity and accuracy in patients with previously failed biopsy procedures.
Journal ArticleDOI
Prevalence of Unsuspected Pancreatic Cysts on MDCT
Thomas A. Laffan,Karen M. Horton,Alison P. Klein,Bruce Berlanstein,Stanley S. Siegelman,Satomi Kawamoto,Pamela T. Johnson,Elliot K. Fishman,Ralph H. Hruban +8 more
TL;DR: In this outpatient population of adult outpatients imaged for disease unrelated to the pancreas, the prevalence of unsuspected pancreatic cysts identified on 16-MDCT was 2.6%.
Journal ArticleDOI
Cystic neoplasms of the pancreas.
William R. Brugge,Gregory Y. Lauwers,Dushyant V. Sahani,Carlos Fernandez-del Castillo,Andrew L. Warshaw +4 more
Journal ArticleDOI
Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis
TL;DR: Most pancreatic cystic tumors should be resected without the need for cyst fluid analysis, however, in asymptomatic patients, in patients with an increased surgical risk, and in patients in whom there is a diagnostic uncertainty about the presence of a PC, cySt fluid analysis helps to determine the optimal therapeutic strategy.
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Jian Wu,Hanno Matthaei,Anirban Maitra,Marco Dal Molin,Laura D. Wood,James R. Eshleman,Michael Goggins,Marcia I. Canto,Richard D. Schulick,Barish H. Edil,Christopher L. Wolfgang,Alison P. Klein,Luis A. Diaz,Peter J. Allen,C. Max Schmidt,Kenneth W. Kinzler,Nickolas Papadopoulos,Ralph H. Hruban,Bert Vogelstein +18 more