Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblastic leukemia
Roland Berger,Alain Bernheim,Marie-Thérèse Daniel,Frangoise Valensi,F Sigaux,Georges Flandrin +5 more
TLDR
A cytologic and cytogenetic study of 10 cases of acute myeloblastic leukemia with maturation and t(8,21) translocation is reported in this article.About:
This article is published in Blood.The article was published on 1982-01-01 and is currently open access. It has received 89 citations till now. The article focuses on the topics: Acute myeloblastic leukemia with maturation & Acute myeloblastic leukemia.read more
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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.
Masakazu Higuchi,Darin P. O’Brien,Parasakthy Kumaravelu,Noel Lenny,Eng-Juh Yeoh,James R. Downing +5 more
TL;DR: The AML1/CBFbeta transcription factor complex, a frequent target of chromosomal translocations in leukemia, is essential for the generation of definitive hematopoietic stem cells.
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Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia
Richard A. Larson,Koji Kondo,James W. Vardiman,Ann E. Butler,Harvey M. Golomb,Janet D. Rowley +5 more
TL;DR: Cytogenetic specimens were obtained from blood or bone marrow in 27 patients with acute promyelocytic leukemia, including four with the microgranular variant, and data indicate that the 15;17 translocation may be found in every patient if optimal chromosome analysis is performed.
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Prognostic impact of c-KIT mutations in core binding factor leukemias. an Italian retrospective study
Roberto Cairoli,Alessandro Beghini,Giovanni Grillo,Gianpaolo Nadali,Francesca Elice,Carla B. Ripamonti,Patrizia Colapietro,Michele Nichelatti,Laura Pezzetti,Monia Lunghi,Antonio Cuneo,Assunta Viola,Felicetto Ferrara,Mario Lazzarino,Francesco Rodeghiero,Giovanni Pizzolo,Lidia Larizza,Enrica Morra +17 more
TL;DR: Findings indicate that c-KIT TKD(816) mutation has a negative impact on the outcome of AML with t(8;21), which is associated with a high white blood cell count at diagnosis and a higher incidence of extramedullary leukemia during the course of the disease.
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Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation.
TL;DR: The Kasumi-1 cell line could be a useful tool for elucidating the pathophysiology of AML with t(8;21) and neither granulocytic nor eosinophilic maturation was observed in the liquid culture by the addition of dimethyl sulfoxide, G-CSF, or IL-5, respectively.
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Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia.
TL;DR: Data suggest that in patients with ANLL, abnormalities of chromosome 3 which simultaneously involve bands 3q21 and 3q26 are associated with unusually high platelet counts.