Journal ArticleDOI
Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus
Wei Jiang,Wei Jiang,Shan Tizhuang,Jia-Jun Xu,Wen-Ju Chen,Li Miao,Mengying Lv,Li Tao,Yan-Qing Liu +8 more
TLDR
Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with six other known abietane-type diterPenoids (2–7) and five known kaurane- type diter penoids (8–12) were isolated and identified from the EtOAc extract of C. orbiculatus.Abstract:
Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with six other known abietane-type diterpenoids (2–7) and five known kaurane-type diterpenoids (8–12) were isolated and identified from the EtOAc extract of C. orbiculatus. Their structures were elucidated on the basis of extensive spectroscopic methods, including UV, IR, HR-ESI–MS, ECD, and NMR experiments, and by comparison with literature data. Compound 1 is a new C19-norabietane diterpenoid with 19 carbons. All compounds except for 10 and 11 were isolated from C. orbiculatus for the first time. The NMR data of 9 were reported for the first time. Compounds 1, 7 and 11 showed cytotoxicities against SGC-7901 with IC50 values of 63.2, 80.9 and 56.7 μM, respectively.read more
Citations
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COE Inhibits Vasculogenic Mimicry by Targeting EphA2 in Hepatocellular Carcinoma, a Research Based on Proteomics Analysis.
Zewen Chu,Xin Shi,Gaoyang Chen,Xuejun He,Yayun Qian,Haibo Wang,Li Tao,Yanqing Liu,Wei Jiang,Jue Chen +9 more
TL;DR: In this paper, the potential targets of COE on anti-VM formation both in vitro and in vivo that are distinct from our previous study were dissected and identified. But, their results indicate that COE could be used in HCC treatment because of its promising antiVM effect.
Journal ArticleDOI
Cytotoxic Dehydroabietylamine Derived Compounds.
TL;DR: This review gives a summary of the most important findings on the cytotoxic behavior of DA-derived compounds but also shows some drawbacks of these, such low bioavailability and/or poor solubility of several derivatives of DA.
Journal ArticleDOI
Metabolomics and molecular docking-directed antiarthritic study of the ethyl acetate extract from Celastrus orbiculatus Thunb.
Mengying Lv,Q. Liang,Xiayun Wan,Zheng Wang,Yayun Qian,Jie Xiang,Zhaoyong Luo,Tengyang Ni,Wei Jiang,Weimin Wang,Haibo Wang,Yan-Ming Liu +11 more
TL;DR: COE at three dosages could significantly relieve paw swelling and reduce arthritis scores of AIA rat and the ultra-high performance liquid chromatography-mass spectrometry based metabolomics proved to be an efficient method to characterize subtle metabolic changes of Aia rats after COE treatment.
Terpenoids-enriched fraction of Celastrus orbiculatus sensitizes gemcitabine by disrupting Chk1/RAD51-mediated DNA damage response in pancreatic cancer
TL;DR: In this paper, a terpenoids-enriched fraction termed TTC (Total Terpenoids of C. orbiculatus) was used as a sensitizer of gemcitabine by targeting DNA damage response in treatment of pancreatic cancer.
References
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Journal ArticleDOI
Antiinflammatory Constituents of Celastrus orbiculatus Inhibit the NF-κB Activation and NO Production
TL;DR: Two new sesquiterpene esters are reported, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran and 1beta-acetoxyl -2beta, 6alpha, 9alpha-trifuroyoxydicelastrol, which showed moderate inhibition in both NF-kappaB activation and nitric oxide production.
Journal ArticleDOI
Immunosuppressive Diterpenoids from Tripterygium wilfordii
Hong-Quan Duan,Yoshihisa Takaishi,Hiroshi Momota,Yasukazu Ohmoto,Takao Taki,Yongfeng Jia,Duan Li +6 more
TL;DR: A clinically used extract of Tripterygium wilfordii afforded three new diterpenoids and the stereochemistry at C-4 of triptonediol was reassigned, and Tripterifordin and 13-epi-manoyl oxide-18-oic acid showed significant inhibitory effects on cytokine production.
Journal ArticleDOI
New diterpenes from Sideritis candicans
TL;DR: Three new diterpenes have been isolated from Sideritis candicans and epicandicandiol 7β-monoacetate as well as epicandicsandiol (VII) have beenisolated from Sidersis candicans.
Journal ArticleDOI
Phenolic diterpenes from Tripterygium wilfordii var. regelii
Yoshihisa Takaishi,Noriko Wariishi,Hideo Tateishi,Kazuyoshi Kawazoe,Kaname Miyagi,Kunhua Li,Hong-Quan Duan +6 more
TL;DR: The triptobenzene A, B, C, D, E, F and G have been isolated from Tripterygium wilfordii var. regelii and their structures have been established on the basis of spectroscopic evidence.
Journal ArticleDOI
Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer.
Haibo Wang,Lide Tao,Tengyang Ni,Hao Gu,Feng Jin,Xiaojun Dai,Jun Feng,Yanbing Ding,Weiming Xiao,Shiyu Guo,Tadashi Hisamitsu,Yayun Qian,Yanqing Liu +12 more
TL;DR: It is indicated that COE not only has significant antiproliferative effects but also has both in vivo and in vitro apoptotic effects, which may provide a basis for the development of new anticancer TCM candidates.