Journal ArticleDOI
Decline in rejection in the first year after pediatric cardiac transplantation: a multi-institutional study
Jeffrey G. Gossett,Charles E. Canter,Jie Zheng,Kenneth B. Schechtman,Elizabeth D. Blume,Sherrie Rodgers,David C. Naftel,James K. Kirklin,Janet Scheel,F.J. Fricker,Paul F. Kantor,Elfriede Pahl +11 more
TLDR
The overall incidence and prevalence of rejection has substantially decreased over time in pediatric HTx recipients in the first year after HTx, but the rate of rejection with hemodynamic compromise or death from rejection remains unchanged.Abstract:
Background Rejection is a major cause of morbidity and mortality after pediatric heart transplantation (HTx). Survival after pediatric HTx has improved over time, but whether there has been an era-related improvement in the occurrence of allograft rejection is unknown. Methods The Pediatric Heart Transplant Study (PHTS) database was queried for patients who underwent HTx from January 1993 to December 2005 to determine the incidence of rejection and identify factors associated with the first episode of rejection in the first year after HTx. Results Data were reviewed in 1,852 patients from 36 centers. The incidence of rejection declined over 13 years at a rate of −2.58 ± 0.41 ( p p p p p = 0.046). Increased risk of rejection was associated with positive donor-specific crossmatch (OR, 1.85; 95% CI, 1.18–2.88; p = 0.007) and older recipient age (OR, 1.05; 95% CI, 1.02–1.07; p Conclusions Although the overall incidence and prevalence of rejection has substantially decreased over time in pediatric HTx recipients in the first year after HTx, the rate of rejection with hemodynamic compromise or death from rejection remains unchanged.read more
Citations
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Journal ArticleDOI
Sensitization in Heart Transplantation: Emerging Knowledge: A Scientific Statement From the American Heart Association.
Monica Colvin,Jennifer L. Cook,Patricia P. Chang,Daphne T. Hsu,Michael S. Kiernan,Jon A. Kobashigawa,JoAnn Lindenfeld,S. Carolina Masri,Dylan V. Miller,E. Rene Rodriguez,Dolly B. Tyan,Adriana Zeevi +11 more
TL;DR: Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.
Journal ArticleDOI
Ten yr of pediatric heart transplantation: a report from the Pediatric Heart Transplant Study.
Anne I. Dipchand,Richard Kirk,William T. Mahle,Margaret Tresler,David C. Naftel,Elfriede Pahl,Shelley D. Miyamoto,Elizabeth D. Blume,Kristine J. Guleserian,Connie White-Williams,James K. Kirklin +10 more
TL;DR: The purpose of this report is to review the last decade of pediatric patients listed for heart transplantation (January 1, 2000–December 31, 2009) and summarize the changes, trends, outcomes, and lessons learned.
Journal ArticleDOI
Current state of pediatric cardiac transplantation
TL;DR: Pediatric heart transplantation continues to evolve in order to address the challenges of the diverse group of patients that reach end-stage heart failure during childhood, and functional outcomes are excellent, but significant psychosocial challenges exist.
Journal ArticleDOI
Long-term outcomes of children after solid organ transplantation
Jon Jin Kim,Stephen D. Marks +1 more
TL;DR: Long-term outcomes of children after kidney, liver, heart, lung and intestinal transplantation are reviewed with an increased focus on reducing longer-term morbidity with improved outcomes in optimizing cardiovascular risk, renal impairment, growth and quality of life.
Journal ArticleDOI
Pediatric heart transplantation—indications and outcomes in the current era
TL;DR: This review focuses on the indications and outcomes for pediatric HTx, with a special emphasis on studies generated by research collaboratives such as the ISHLT and the Pediatric Heart Transplant Study (PHTS) group.
References
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Journal ArticleDOI
Revision of the 1990 Working Formulation for the Standardization of Nomenclature in the Diagnosis of Heart Rejection
Susan Stewart,Michael C. Fishbein,G.I. Snell,Gerald J. Berry,Annette Boehler,Margaret Burke,A. Glanville,F. Kate Gould,Cynthia Magro,Charles C. Marboe,K. McNeil,Elaine F. Reed,Nancy L. Reinsmoen,John P. Scott,Sean M. Studer,Henry D. Tazelaar,John Wallwork,G.P. Westall,Martin Zamora,Adriana Zeevi,Samuel A. Yousem +20 more
TL;DR: This article summarizes the revised consensus classification of lung allograft rejection and recommends the evaluation of antibody-mediated rejection, recognizing that this is a controversial entity in the lung, less well developed and understood than in other solid-organ grafts, and with no consensus reached on diagnostic features.
Journal Article
A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation.
Margaret E. Billingham,N. R. B. Cary,M. E. Hammond,J. Kemnitz,Charles C. Marboe,H. A. Mccallister,D. C. Snovar,Gayle L. Winters,A. Zerbe +8 more
Journal ArticleDOI
Registry of the International Society for Heart and Lung Transplantation: Twelfth Official Pediatric Heart Transplantation Report-2009.
Richard Kirk,Leah B. Edwards,Paul Aurora,David O. Taylor,Jason D. Christie,Fabienne Dobbels,Anna Y. Kucheryavaya,Axel O. Rahmel,Josef Stehlik,Marshall I. Hertz +9 more
TL;DR: This report documents the recent rise in the number of re-transplant procedures and further evaluates the late outcomes after re- Transplantation, and reports on a more complete knowledge base for late survival and morbidity as late as 10 years after transplantation.
Journal Article
Registry of the International Society for Heart and Lung Transplantation: tenth official pediatric heart transplant report-2007
Mark M. Boucek,Paul Aurora,Leah B. Edwards,David O. Taylor,Elbert P. Trulock,Jason D. Christie,Fabienne Dobbels,Axel O. Rahmel,Berkeley M. Keck,Marshall I. Hertz +9 more
Journal ArticleDOI
Antibody-mediated rejection in human cardiac allografts: evaluation of immunoglobulins and complement activation products C4d and C3d as markers.
E. R. Rodriguez,Diane V. Skojec,Carmela D. Tan,Andrea A. Zachary,Edward K. Kasper,John V. Conte,William M. Baldwin +6 more
TL;DR: Systematic evaluation of endomyocardial biopsies is not improved by the use of antibodies for immunoglobulins or C1q, and concomitant use of C4d and C3d is very useful to diagnose AMR, when correlated with clinical parameters of graft function.
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