Dengue Virus Infection in Africa
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TLDR
Dengue is likely underrecognized and underreported in Africa because of low awareness by health care providers, other prevalent febrile illnesses, and lack of diagnostic testing and systematic surveillance.Abstract:
Reported incidence of dengue has increased worldwide in recent decades, but little is known about its incidence in Africa. During 1960-2010, a total of 22 countries in Africa reported sporadic cases or outbreaks of dengue; 12 other countries in Africa reported dengue only in travelers. The presence of disease and high prevalence of antibody to dengue virus in limited serologic surveys suggest endemic dengue virus infection in all or many parts of Africa. Dengue is likely underrecognized and underreported in Africa because of low awareness by health care providers, other prevalent febrile illnesses, and lack of diagnostic testing and systematic surveillance. Other hypotheses to explain low reported numbers of cases include cross-protection from other endemic flavivirus infections, genetic host factors protecting against infection or disease, and low vector competence and transmission efficiency. Population-based studies of febrile illness are needed to determine the epidemiology and true incidence of dengue in Africa.read more
Citations
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Full-length genome sequence of a dengue serotype 1 virus isolate from a traveler returning from Democratic Republic of Congo to Italy, July 2019.
Francesca Colavita,Francesco Vairo,Fabrizio Carletti,Chiara Boccardo,Federica Ferraro,Giancarlo Iaiani,Samir Al Moghazi,Gioacchino Galardo,Eleonora Lalle,Carla Selvaggi,Paola Scognamiglio,Maria Rosaria Capobianchi,Giuseppe Ippolito,Concetta Castilletti +13 more
TL;DR: The full-genome sequence of a Dengue serotype-1 virus (DENV-1) isolated from a traveller returning in July 2019 to Italy from Democratic Republic of Congo shows high similarity with two 2013 strains isolated in Angola and China.
Posted ContentDOI
Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018
Amy Gaye,Tolla Ndiaye,Mouhamad Sy,Awa B. Deme,Alphonse B. Thiaw,Aita Sene,Cheikh Ndiaye,Younouss Diedhiou,Amadou Moctar Mbaye,Ibrahima Ndiaye,Christopher Tomkins-Tinch,Christopher Tomkins-Tinch,Jules F. Gomis,Aida Sadikh Badiane,Bronwyn MacInnis,Daniel J. Park,Mouhamadou Falilou Ndiaye,Ngayo Sy,Pardis C. Sabeti,Katherine J. Siddle,Katherine J. Siddle,Daouda Ndiaye +21 more
TL;DR: This work used molecular tools including metagenomic sequencing to identify 19 previously undetected dengue virus cases from the city of Thies and assemble 17 complete virus genomes, finding DENV3 was the most frequent serotype and Sequences were closest to recent sequences from West Africa.
Journal ArticleDOI
Dengue virus infection and pregnancy outcomes during the 2017 outbreak in Ouagadougou, Burkina Faso: A retrospective cohort study.
Serge Alain Tougma,W. Noélie Zoungrana,Yaméogo,Désiré Lucien Dahourou,Ida Adéline Salou,Kagoné,T. Rébeca Compaoré,Ahmed Kabore,Thérèse Kagoné,Maxime Drabo,Nicolas Meda +10 more
TL;DR: D Dengue fever is a risk factor for adverse pregnancy outcomes, especially in the third trimester in Burkina Faso, and the implementation of effective anti-vectorial control interventions and better management of dengue fever during pregnancy are needed to improve pregnancy outcomes.
Journal ArticleDOI
Elimination of Falciparum Malaria and Emergence of Severe Dengue: An Independent or Interdependent Phenomenon?
TL;DR: It is speculated that malaria infection elicits cross-reactive antibodies or other immune responses that infer cross-protection, or at least partial cross- protection, against symptomatic and severe dengue, and that this inter-species cross- Protection may explain the near absence of severe d Dengue from the Sub-Saharan region and parts of South Asia until recently.
Journal ArticleDOI
Serological Survey of Dengue Virus Immunoglobulin M Among Febrile Patients in Kaduna Metropolis, Nigeria
TL;DR: There was no statistically significant association between the occurrence of dengue virus IgM and potential risk factors, demographic factors and symptoms of the illness.
References
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Journal ArticleDOI
Dengue and Dengue Hemorrhagic Fever
TL;DR: A review of the changing epidemiology of dengue and hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both Dengue fever and DVF, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control can be found in this paper.
Dengue and dengue hemorrhagic fever.
TL;DR: A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.
Journal ArticleDOI
Spectrum of Disease and Relation to Place of Exposure among Ill Returned Travelers
David O. Freedman,Leisa H. Weld,Phyllis E. Kozarsky,Tamara L. Fisk,Rachel Robins,Frank von Sonnenburg,Jay S. Keystone,Prativa Pandey,Martin S. Cetron +8 more
TL;DR: When patients present to specialized clinics after travel to the developing world, travel destinations are associated with the probability of the diagnosis of certain diseases, and diagnostic approaches and empiric therapies can be guided by these destination-specific differences.
Journal ArticleDOI
Dengue: the risk to developed and developing countries
TL;DR: At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti.
Journal ArticleDOI
Dengue/dengue hemorrhagic fever: the emergence of a global health problem.
Duane J. Gubler,Gary G. Clark +1 more
TL;DR: The near simultaneous occurrence of outbreaks of dengue fever on three continents indicates that these viruses and their mosquito vector have had a worldwide distribution in the tropics for more than 200 years.
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