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Design and Antitumor Activity of Platinum Complexes
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In this paper, the main advances in the design of antitumor platinum complexes over the last five years are presented, with particular attention paid to unconventional Pt(IV) complexes (complexes with S and P donor ligands).Abstract:
This review presents the main advances in the design of antitumor platinum complexes over the last five years. Particular attention is paid to unconventional antitumor platinum compounds (complexes in the trans configuration, Pt(IV) complexes with S and P donor ligands, multinuclear complexes).read more
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Trends in the Usage of Bidentate Phosphines as Ligands in Nickel Catalysis.
TL;DR: This Review is a comprehensive overview of reactions catalyzed by nickel and an added bidentate phosphine, focusing on the steps transforming the combination of precatalyst and ligand into an active catalyst and the potential effects of this transformation on nickel catalysis.
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
TL;DR: There has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs.
Journal ArticleDOI
V-shaped bis-coumarin based fluorescent probe for detecting palladium in natural waters.
TL;DR: A catalytic fluorescent probe based on V-shaped bis-coumarin has been designed and synthesized for detection of palladium and has good selectivity and high sensitivity and has been successfully applied to detection of Palladium in environmental waters.
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Syntheses, crystal structures, and biological evaluations of new dinuclear platinum(II) complexes with 1,2,4-triazole derivatives as bridging ligands
TL;DR: A series of new dinuclear platinum(ii) complexes with the general formula [Pt2(μ-HL)4] (1-4), where H 2L is 4-[(5-chloro-2-hydroxy-benzylidene)-amino]-3-R-1,2,4-triazole-5thione: R = H (1), methyl (2), ethyl (3) and propyl (4), were synthesized and characterized.
Journal ArticleDOI
Cisplatin−cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line
TL;DR: In this paper , three conjugates based on a cisplatin scaffold bearing the anti-inflammatory drugs naproxen, ibuprofen or flurbiprofen in the axial positions (1, 2 and 3, respectively) were synthesised and loaded into SBA-15 to afford the mesoporous silica nanoparticles.
References
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Journal ArticleDOI
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
TL;DR: Recently, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs as mentioned in this paper.
Journal ArticleDOI
Platinum-based drugs: past, present and future.
Shahana Dilruba,Ganna V. Kalayda +1 more
TL;DR: The main classes of new platinum drug candidates, such as sterically hindered complexes, monofunctional platinum drugs, complexes with biologically active ligands, trans-configured and polynuclear platinum complexes, platinum(IV) prodrugs and platinum-based drug delivery systems are reviewed.
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Synthetic Methods for the Preparation of Platinum Anticancer Complexes
TL;DR: The demonstration in the 1960's that cis-diamminedichloroplatinum(II), or cisplatin, inhibits cellular division of Escherichia coli1 led to the subsequent discovery that this simple coordination compound is also an effective antitumor agent in mouse models.
Journal ArticleDOI
Platinum coordination compounds with potent anticancer activity
Krishant M Deo,Dale L. Ang,Brondwyn McGhie,Adeline Rajamanickam,Ankita Dhiman,Aleen Khoury,Jason Holland,Aleksandra Bjelosevic,Benjamin J. Pages,Christopher P. Gordon,Janice R. Aldrich-Wright +10 more
TL;DR: A review of the history and development of platinum(II) and platinum(IV) complexes can be found in this article, where the authors provide some background in the development of these complexes.
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Research progress in modern structure of platinum complexes.
Bai Linkui,Chuanzhu Gao,Liu Qinghua,Congtao Yu,Zhuxin Zhang,Linxiang Cai,Bo Yang,Yunxu Qian,Jian Yang,Xiali Liao +9 more
TL;DR: Overall, platinum-based anticancer complexes reported recently years upon modern structure are emphasized and showed the potential to be developed as novel type of anticancer agents.