Journal ArticleDOI
Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA.
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TLDR
Novel triphenylethylene-coumarin hybrid derivatives containing different amounts of amino side chains were designed and synthesized in good yields under microwave radiation and suggested that the amino alkyl chain would play an important role in the compounds against tumor cells proliferation and their interactions with DNA.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2013-09-01. It has received 54 citations till now. The article focuses on the topics: Side chain & Circular dichroism.read more
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Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
TL;DR: This is the first standalone review that emphasis on the assorted retrosynthetic approaches, important targets for molecularly targeted cancer therapy and structure activity relationship studies that highlight the chemical groups responsible for evoking the anticancer potential of coumarin derivatives reported from 2011 to 2014.
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Current developments of coumarin-based anti-cancer agents in medicinal chemistry
Saeed Emami,Sakineh Dadashpour +1 more
TL;DR: The current developments of coumarin-based anticancer agents are covered and the structure-activity relationship of the most potent compounds are discussed.
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Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
TL;DR: An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
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An overview of molecular hybrids in drug discovery.
TL;DR: This review covers the main research published between early 2013 to mid-2015 and takes into account several previous reviews on the subject, with particular attention given to anticancer hybrids.
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Recent developments of C-4 substituted coumarin derivatives as anticancer agents.
TL;DR: A synthetic strategy for the preparation of C-4 substituted coumarin derivatives as anticancer agents based on their mechanism of action is given and the SAR of the most active compound is discussed.
References
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Impact of natural products on developing new anti-cancer agents
TL;DR: This work presents a meta-analysis of the “Metagenome” of Cyanophytes and Marine Microbes, which highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.
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On demonstrating DNA intercalation
TL;DR: Only a fraction of known DNA-interactive agents have been structurally characterized to atomic detail in noncovalent complexes with DNA.
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Interactions of porphyrins with nucleic acids
TL;DR: These results corroborate previous static studies, utilizing visible spectroscopy and circular dichroism, which indicate that the formation of an intercalated complex occurs only at GC base pair sites with porphyrins which do not possess axial ligands.
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Hybrid molecules with a dual mode of action: dream or reality?
TL;DR: In order to obtain new antimalarial drugs that are affordable and able to avoid the emergence of resistant strains, the authors developed hybrid molecules with a dual mode of action able to kill multiresistant strains by oral administration.
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