Journal ArticleDOI
Current developments of coumarin-based anti-cancer agents in medicinal chemistry
Saeed Emami,Sakineh Dadashpour +1 more
TLDR
The current developments of coumarin-based anticancer agents are covered and the structure-activity relationship of the most potent compounds are discussed.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2015-09-18. It has received 352 citations till now.read more
Citations
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Journal ArticleDOI
Coumarin-Based Small-Molecule Fluorescent Chemosensors.
Duxia Cao,Zhiqiang Liu,Peter Verwilst,Seyoung Koo,Paramesh Jangjili,Jong Seung Kim,Weiying Lin,Weiying Lin +7 more
TL;DR: This comprehensive and critical review of coumarin-based small-molecule fluorescent chemosensors during the period of 2012-2018 may facilitate the development of more powerful fluorescent chemOSensors for broad and exciting applications in the future.
Journal ArticleDOI
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.
Sakineh Dadashpour,Saeed Emami +1 more
TL;DR: The present article aims to review the current application of indole core in the design of new anticancer agents that may act via various targets such as histone deacetylases, sirtuins, PIM kinases, DNA topoisomerases and σ receptors.
Journal ArticleDOI
A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade.
Xiaoxia Liang,Wu Qiang,Shangxian Luan,Zhongqiong Yin,Changliang He,Lizi Yin,Yuanfeng Zou,Yuan Zhixiang,Lixia Li,Xu Song,Min He,Cheng Lv,Wei Zhang +12 more
TL;DR: This review summarizes types of topoisomerase inhibitors in the past decade, and divides them into nine classes by structural characteristics, including N-heterocycles compounds, quinone derivatives, flavonoids derivatives, coumarin derivatives, lignan derivatives, polyphenol derivatives, diterpenes derivatives, fatty acids derivatives, and metal complexes.
Journal ArticleDOI
Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole-coumarin hybrids.
Tatjana Gazivoda Kraljević,Anja Harej,Mirela Sedić,Sandra Kraljević Pavelić,Višnja Stepanić,Domagoj Drenjančević,Jasminka Talapko,Silvana Raić-Malić +7 more
TL;DR: It is indicated that coumarin-1,2,3-triazole could be used as the scaffold for structural optimization to develop more potent and selective anticancer agents and encourage further development of novel structurally related analogs of 33 as more effective 5-LO inhibitors.
Journal ArticleDOI
Recent advances and perspectives in the synthesis of bioactive coumarins
TL;DR: In this paper, the authors highlight the most recent synthetic advances that make use of non-conventional methods and energy sources and some perspectives for the future, in particular the synthesis of new hybrid molecules bearing a coumarin moiety with a dual mode of biological action.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
Thomas U. Mayer,Tarun M. Kapoor,Stephen J. Haggarty,Stephen J. Haggarty,Randall W. King,Stuart L. Schreiber,Stuart L. Schreiber,Timothy J. Mitchison +7 more
TL;DR: In vitro, monastrol specifically inhibited the motility of the mitotic kinesin Eg5, a motor protein required for spindle bipolarity, and will therefore be a particularly useful tool for studying mitotic mechanisms.