Journal ArticleDOI
Designer cathinones--an emerging class of novel recreational drugs.
Reads0
Chats0
TLDR
This review surveys the current state of knowledge regarding the pharmacotoxicological properties of synthetic cathinones, the prevalence and pattern of their use, and the negative consequences of using these products including, among others, cardiovascular, psychiatric and neurologic symptoms, dehydration, rhambdomyolysis, renal and liver failure.About:
This article is published in Forensic Science International.The article was published on 2013-09-10. It has received 174 citations till now. The article focuses on the topics: Bath salts & Mephedrone.read more
Citations
More filters
Journal ArticleDOI
Wastewater-based epidemiology biomarkers: Past, present and future
Phil M. Choi,Benjamin J. Tscharke,Erica Donner,Jake W. O'Brien,Sharon Grant,Sarit Kaserzon,Rachel Mackie,Elissa O'Malley,Nicholas D. Crosbie,Kevin V. Thomas,Jochen F. Mueller +10 more
TL;DR: In this article, a review summarises the established wastewater-based epidemiology (WBE) biomarkers, and presents a critical review of the current capabilities of WBE, and discuss possible future strategies and challenges anticipated in analysing wastewater to measure chemical markers of population health as well as biological markers of microbial exposure and disease.
Journal ArticleDOI
Synthetic Cathinones: A New Public Health Problem
TL;DR: The major clinical effects of synthetic cathinones are reviewed to highlight their impact on public health.
Journal ArticleDOI
GHB Pharmacology and Toxicology: Acute Intoxication, Concentrations in Blood and Urine in Forensic Cases and Treatment of the Withdrawal Syndrome
TL;DR: There is no evidence-based protocol available to deal with GHB withdrawal, apart from administering benzodiazepines, and effective antidotes to reverse the sedative and intoxicating effects of GHB do not exist.
Journal ArticleDOI
Synthetic Cathinone and Cannabinoid Designer Drugs Pose a Major Risk for Public Health.
TL;DR: Given the rapid increase in the use of synthetic cathinones and cannabinoid designer drugs, their potential for dependence and abuse, and harmful medical and psychiatric effects, there is a need for research and education in the areas of prevention and treatment.
Journal ArticleDOI
Next generation of novel psychoactive substances on the horizon - A complex problem to face.
TL;DR: This review presents updated information on the second generation of NPS, introduced as replacements of the already banned substances from this class, focusing on their pharmacological properties and metabolism, routes of administration, and effects in humans.
References
More filters
Journal ArticleDOI
The Toxicology of Bath Salts: A Review of Synthetic Cathinones
Jane M. Prosser,Lewis S. Nelson +1 more
TL;DR: Exposure to and use of synthetic cathinones are becoming increasingly popular despite a lack of scientific research and understanding of the potential harms of these substances.
Journal ArticleDOI
Pharmacological characterization of designer cathinones in vitro
Linda D. Simmler,T. A. Buser,Massimiliano Donzelli,York Schramm,L. H. Dieu,Jörg Huwyler,Sylvie Chaboz,Marius C. Hoener,Matthias E. Liechti +8 more
TL;DR: Designer β‐keto amphetamines (e.g. cathinones, ‘bath salts’ and ‘research chemicals’) have become popular recreational drugs, but their pharmacology is poorly characterized.
Journal ArticleDOI
Clinical experience with and analytical confirmation of “bath salts” and “legal highs” (synthetic cathinones) in the United States
TL;DR: The emergence of a new group of substances of abuse in the USA, known as bath salts, is reported with quantitative results in 18 patients, the first report of MDPV exposures with quantitative blood level confirmation.
Journal ArticleDOI
The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue
Michael H. Baumann,Mario A. Ayestas,John S. Partilla,Jacquelyn R. Sink,Alexander T. Shulgin,Paul F. Daley,Simon D. Brandt,Richard B. Rothman,Arnold E. Ruoho,Nicholas V. Cozzi +9 more
TL;DR: In vitro and in vivo methods demonstrate that designer methcathinone analogs are substrates for monoamine transporters, with a profile of transmitter-releasing activity comparable to MDMA.
Journal ArticleDOI
Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products.
Michael H. Baumann,John S. Partilla,Kurt R. Lehner,Eric B. Thorndike,Alexander F. Hoffman,Marion Holy,Richard B. Rothman,Steven R. Goldberg,Carl R. Lupica,Harald H. Sitte,Simon D. Brandt,Srihari R. Tella,Nicholas V. Cozzi,Charles W. Schindler +13 more
TL;DR: The data show that MDPV is a monoamine transporter blocker with increased potency and selectivity for catecholamines when compared with cocaine, and may provide a mechanism to explain the adverse effects observed in humans taking high doses of ‘bath salts’ preparations.
Related Papers (5)
The Toxicology of Bath Salts: A Review of Synthetic Cathinones
Jane M. Prosser,Lewis S. Nelson +1 more