Journal ArticleDOI
Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview
Joep E. G. IJspeert,Roisin Bevan,Carlo Senore,Michal F. Kaminski,Ernst J. Kuipers,Andrzej Mróz,Xavier Bessa,Paola Cassoni,Cesare Hassan,Alessandro Repici,Francesc Balaguer,Colin J Rees,Evelien Dekker +12 more
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TLDR
The detection rate of SPs is variable among screening cohorts, and standards for reporting, detection and histopathological assessment should be established to define uniform minimum standards for males and females between 50 and 75 years of age.Abstract:
Objective The role of serrated polyps (SPs) as colorectal cancer precursor is increasingly recognised. However, the true prevalence SPs is largely unknown. We aimed to evaluate the detection rate of SPs subtypes as well as serrated polyposis syndrome (SPS) among European screening cohorts. Methods Prospectively collected screening cohorts of ≥1000 individuals were eligible for inclusion. Colonoscopies performed before 2009 and/or in individuals aged below 50 were excluded. Rate of SPs was assessed, categorised for histology, location and size. Age–sex–standardised number needed to screen (NNS) to detect SPs were calculated. Rate of SPS was assessed in cohorts with known colonoscopy follow-up data. Clinically relevant SPs (regarded as a separate entity) were defined as SPs ≥10 mm and/or SPs >5 mm in the proximal colon. Results Three faecal occult blood test (FOBT) screening cohorts and two primary colonoscopy screening cohorts (range 1.426–205.949 individuals) were included. Rate of SPs ranged between 15.1% and 27.2% (median 19.5%), of sessile serrated polyps between 2.2% and 4.8% (median 3.3%) and of clinically relevant SPs between 2.1% and 7.8% (median 4.6%). Rate of SPs was similar in FOBT-based cohorts as in colonoscopy screening cohorts. No apparent association between the rate of SP and gender or age was shown. Rate of SPS ranged from 0% to 0.5%, which increased to 0.4% to 0.8% after follow-up colonoscopy. Conclusions The detection rate of SPs is variable among screening cohorts, and standards for reporting, detection and histopathological assessment should be established. The median rate, as found in this study, may contribute to define uniform minimum standards for males and females between 50 and 75 years of age.read more
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Journal ArticleDOI
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia
TL;DR: Variations in rate of endoscopic detection of serrated polyps indicate the need for careful examination, with adequate bowel preparation and sufficient withdrawal times, and concerns regarding incomplete detection and resection.
Journal ArticleDOI
Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.
Priyanka Kanth,Jade Grimmett,Marjan Champine,Randall W. Burt,N. Jewel Samadder,N. Jewel Samadder,N. Jewel Samadder +6 more
TL;DR: A narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.
Journal ArticleDOI
Providing data for serrated polyp detection rate benchmarks: an analysis of the New Hampshire Colonoscopy Registry.
Joseph C. Anderson,Joseph C. Anderson,Lynn F. Butterly,Lynn F. Butterly,Julia E. Weiss,Christina M. Robinson +5 more
TL;DR: Derived from ADR, the primary colonoscopy quality indicator, the results suggest potential SDR benchmarks that may guide adequate serrated polyp detection that may be essential to the prevention of CRC associated with the serrated pathway.
Journal ArticleDOI
Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks.
Tsuyoshi Ozawa,Soichiro Ishihara,Mitsuhiro Fujishiro,Youichi Kumagai,Satoki Shichijo,Tomohiro Tada +5 more
TL;DR: The authors' deep convolutional neural network architecture showed promise in being able to detect and classify CP through endoscopic images, highlighting its high potential for future application as an AI-based CP diagnosis support system for colonoscopy.
Journal ArticleDOI
Expert opinions and scientific evidence for colonoscopy key performance indicators
Colin J Rees,Roisin Bevan,Katharina Zimmermann-Fraedrich,Matthew D. Rutter,Douglas K. Rex,Evelien Dekker,Thierry Ponchon,Michael Bretthauer,Jaroslaw Regula,Brian Saunders,Cesare Hassan,Michael J. Bourke,Thomas Rösch +12 more
TL;DR: The scientific basis for each of the quality measures published in the UK standards for colorectal cancer screening are reviewed.
References
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Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths
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