Journal ArticleDOI
The evolution of cancer of the colon and rectum.
TLDR
Evidence is presented which suggests that most cancers of the colon and rectum have evolved through the polyp‐cancer sequence although the majority of adenomas do not become cancerous during a normal adult life span.Abstract:
The malignant potential of adenomas of the colon and rectum varies with size, histological type and grade of epithelial atypia. The adenomatous polyp is usually small and has a low malignant potential, whereas tumors with a villous structure are usually larger and have a much higher cancer rate. Severe atypia is more common in villous adenomas than in adenomatous polyps. Evidence is presented which suggests that most cancers of the colon and rectum have evolved through the polyp-cancer sequence although the majority of adenomas do not becoma cancerous during a normal adult life span. The slow evolution of the polyp-cancer sequence is stressed. The implications of the polyp-cancer sequence for the design of cancer prevention programmes and the study of the aetiology of large bowel cancer are discussed.read more
Citations
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Journal ArticleDOI
Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.
Sidney J. Winawer,A G Zauber,M N Ho,Michael J. O'Brien,Leonard S. Gottlieb,S S Sternberg,Jerome D. Waye,Melvin Schapiro,John H. Bond,Joel F. Panish +9 more
TL;DR: The results of the National Polyp Study support the view that colorectal adenomas progress to adenocarcinomas, as well as the current practice of searching for and removing adenomatous polyps to prevent coloreCTal cancer.
Journal ArticleDOI
Annual Report to the Nation on the Status of Cancer, 1975-2006, Featuring Colorectal Cancer Trends and Impact of Interventions (Risk Factors, Screening, and Treatment) to Reduce Future Rates
Brenda K. Edwards,Elizabeth Ward,Betsy A. Kohler,Christie R. Eheman,Ann G. Zauber,Robert N. Anderson,Ahmedin Jemal,Maria J. Schymura,Iris Lansdorp-Vogelaar,Laura C. Seeff,Marjolein van Ballegooijen,S. Luuk Goede,Lynn A. G. Ries +12 more
TL;DR: This year's report includes trends in colorectal cancer incidence and death rates and highlights the use of microsimulation modeling as a tool for interpreting past trends and projecting future trends to assist in cancer control planning and policy decisions.
Journal ArticleDOI
Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
Robert H. Riddell,Harvey Goldman,David F. Ransohoff,Henry D. Appelman,Cecilia M. Fenoglio,Rodger C. Haggitt,Christer hren,Pelayo Correa,Stanley R. Hamilton,B C Morson,Sheldon C. Sommers,John H. Yardley +11 more
TL;DR: A classification system for the epithelial changes that occur in ulcerative colitis was developed, which should be applicable to other forms of inflammatory bowel disease as well and makes use of standardized terminology, addresses specific problem areas, and offers practical solutions.
The Paris endoscopic classification of superficial neoplastic lesions : esophagus, stomach and colon.
H. Inoue,Hiroshi Kashida,Shin-ei Kudo,M. Sasako,T Shimoda,H Watanabe,Shigeto Yoshida,M. Guelrud,Charles J. Lightdale,Kenneth K. Wang,Robert H. Riddell,Diebold,R Lambert,JF Rey,Michael E. Jung,Horst Neuhaus,A. T. R. Axon,Robert M. Genta,J. J. Gonvers +18 more
TL;DR: An international group of endoscopists, surgeons, and pathologists gathered in Paris for an intensive workshop designed to explore the utility and clinical relevance of the Japanese endoscopic classification of superficial neoplastic lesions of the GI tract.
Journal ArticleDOI
Systemic complications of acromegaly: epidemiology, pathogenesis, and management.
TL;DR: The most important cause of morbidity and functional disability of this disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years.
References
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Journal ArticleDOI
Bacteria and ætiology of cancer of large bowel
Michael J. Hill,B. S. Drasar,Gabrielle Hawksworth,Vivienne C. Aries,J. S. Crowther,R.E.O. Williams +5 more
TL;DR: Faeces from people in the " Western " countries contained higher concentrations of steroids than those from the African and Eastern countries, and the steroids were also more degraded, consonant with the thesis that the intestinal bacteria may be aetiologically related to cancer of the colon.
Journal ArticleDOI
Rectal biopsy as an aid to cancer control in ulcerative colitis.
B C Morson,L S Pang +1 more
TL;DR: The detection of epithelial changes suggestive of precancer or carcinoma in situ in rectal biopsies from patients with ulcerative colitis prompted an investigation into the incidence and extent of such changes in colectomy specimens removed for colitis with and without malignant change.
Journal ArticleDOI
Bacteria and the aetiology of cancer of the large bowel.
TL;DR: The bacterial flora of the faeces from people in England, an area with a high incidence of cancer of the large bowel, with that of people in Uganda, where the incidence is low are compared.
Journal ArticleDOI
Family studies in cancer of the colon and rectum.
TL;DR: Family histories were obtained from 209 patients undergoing treatment for cancer of the colon or rectum at St Mark's Hospital and parents and siblings who had died, and the number of deaths was more than three times that expected for a comparable group from the general population.
Book
Familial Polyposis Coli
TL;DR: It is shown that Handford (1890) appears to have been the first to notice the high incidence of associated carcinoma of the colon and rectum and this observation has important consequences in the study of the etiology of intestinal cancer.