Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel
Douglas K. Rex,Dennis J. Ahnen,John A. Baron,Kenneth P. Batts,Carol A. Burke,Randall W. Burt,John R. Goldblum,Jose G. Guillem,Charles J. Kahi,Matthew F. Kalady,Michael J. O'Brien,Robert D. Odze,Shuji Ogino,Susan Parry,Susan Parry,Dale C. Snover,Emina Torlakovic,Paul E. Wise,Joanne P. Young,James M. Church +19 more
TLDR
It is recommended that all serrated lesions proximal to the sigmoid colon and allserrated lesions in the rectosigmoid >5 mm in size, be completely removed.About:
This article is published in The American Journal of Gastroenterology.The article was published on 2012-09-01 and is currently open access. It has received 951 citations till now. The article focuses on the topics: Sessile serrated adenoma & Hyperplastic Polyp.read more
Citations
More filters
Journal ArticleDOI
Multitarget Stool DNA Testing for Colorectal-Cancer Screening
Thomas F. Imperiale,David F. Ransohoff,Steven H. Itzkowitz,Theodore R. Levin,Philip T. Lavin,Graham P. Lidgard,David A. Ahlquist,Barry M. Berger +7 more
TL;DR: In asymptomatic persons at average risk for colorectal cancer, multitarget stool DNA testing detected significantly more cancers than did FIT but had more false positive results.
Journal ArticleDOI
Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy
Reiko Nishihara,Kana Wu,Paul Lochhead,Teppei Morikawa,Xiaoyun Liao,Zhi Rong Qian,Kentaro Inamura,Sun A. Kim,Aya Kuchiba,Mai Yamauchi,Yu Imamura,Walter C. Willett,Bernard Rosner,Charles S. Fuchs,Edward Giovannucci,Shuji Ogino,Andrew T. Chan +16 more
TL;DR: Colorectal cancer diagnosed within 5 years after colonoscopy was more likely than cancer diagnosed after that period or without prior endoscopy to have CIMP and microsatellite instability and colonoscopic was also associated with a modest reduction in the incidence of proximal colon cancer.
Journal ArticleDOI
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Sapna Syngal,Randall E. Brand,James M. Church,Francis M. Giardiello,Heather Hampel,Randall W. Burt +5 more
TL;DR: Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers.
Journal ArticleDOI
Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline
Monika Ferlitsch,Alan C. Moss,Cesare Hassan,Pradeep Bhandari,Jean-Marc Dumonceau,Gregorios A. Paspatis,Rodrigo Jover,Cord Langner,Maxime E. S. Bronzwaer,Kumanan Nalankilli,Paul Fockens,Rawi Hazzan,Ian M. Gralnek,Michael Gschwantler,Elisabeth Waldmann,Philip Jeschek,D Penz,D. Heresbach,Leon M G Moons,Arnaud Lemmers,Konstantina D. Paraskeva,Juergen Pohl,Thierry Ponchon,Jaroslaw Regula,Alessandro Repici,Matthew D. Rutter,Nicholas G. Burgess,Nicholas G. Burgess,Michael J. Bourke,Michael J. Bourke +29 more
TL;DR: ESGE recommends that the goals of endoscopic mucosal resection (EMR) are to achieve a completely snare-resected lesion in the safest minimum number of pieces, with adequate margins and without need for adjunctive ablative techniques.
Journal ArticleDOI
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Rodrigo Dienstmann,Louis Vermeulen,Justin Guinney,Scott Kopetz,Sabine Tejpar,Josep Tabernero +5 more
TL;DR: Better characterization of the transcriptomic subtypes of colorectal cancer, encompassing tumour, stromal and immune components, has revealed convergent pathway dependencies that mandate a 'multi-molecular' perspective for the development of therapies to treat this disease.
References
More filters
Journal ArticleDOI
CpG island methylator phenotype in colorectal cancer.
Minoru Toyota,Nita Ahuja,Mutsumi Ohe-Toyota,James G. Herman,Stephen B. Baylin,Jean Pierre J. Issa +5 more
TL;DR: A pathway in colorectal cancer appears to be responsible for the majority of sporadic tumors with mismatch repair deficiency, and is defined as CpG island methylator phenotype (CIMP); CIMP+ tumors also have a high incidence of p16 and THBS1 methylation, and they include the majority with microsatellite instability related to hMLH 1 methylation.
Journal ArticleDOI
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Daniel J. Weisenberger,Kimberly D. Siegmund,Mihaela Campan,Joanne P. Young,Tiffany I. Long,Mark A Faasse,Gyeong Hoon Kang,Martin Widschwendter,Deborah Weener,Daniel D. Buchanan,Hoey Koh,Lisa A. Simms,Melissa A. Barker,Barbara A. Leggett,Joan Levine,Myungjin Kim,Amy J. French,Stephen N. Thibodeau,Jeremy R. Jass,Robert W. Haile,Peter W. Laird +20 more
TL;DR: A systematic, stepwise screen of 195 CpG island methylation markers using MethyLight technology found that CIMP-positive (CIMP+) tumors convincingly represent a distinct subset, encompassing almost all cases of tumors with BRAFmutation (odds ratio = 203).
Journal ArticleDOI
Quality Indicators for Colonoscopy and the Risk of Interval Cancer
Michal F. Kaminski,Jaroslaw Regula,Ewa Kraszewska,Marcin Polkowski,Urszula Wojciechowska,Joanna Didkowska,Maria Zwierko,Maciej Rupinski,M. Nowacki,Eugeniusz Butruk +9 more
TL;DR: The adenoma detection rate is an independent predictor of the risk of interval colorectal cancer after screening colonoscopy, and the rate of cecal intubation was not significantly associated with this risk.
Journal ArticleDOI
Polyp miss rate determined by tandem colonoscopy: a systematic review.
Jeroen C. van Rijn,Johannes B. Reitsma,Jaap Stoker,Patrick M.M. Bossuyt,Sander J. H. van Deventer,Evelien Dekker +5 more
TL;DR: Colonoscopy rarely misses polyps ≥10 mm, but the miss rate increases significantly in smaller sized polyps.
Journal ArticleDOI
Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines: Report From an American College of Chest Physicians Task Force
Gordon H. Guyatt,David D. Gutterman,Michael H. Baumann,Doreen Addrizzo-Harris,Elaine M. Hylek,Barbara Phillips,Gary E. Raskob,Sandra Zelman Lewis,Holger J. Schünemann +8 more
TL;DR: An American College of Chest Physicians task force formulated the criteria for a grading system to be utilized in all ACCP guidelines that included simplicity and transparency, explicitness of methodology, and consistency with current methodological approaches to the grading process.