Developing a Progressive Control Pathway for African Animal Trypanosomosis
O. Diall,Giuliano Cecchi,Gift Wanda,Rafael Argilés-Herrero,Marc J. B. Vreysen,Giovanni Cattoli,Gerrit J. Viljoen,Raffaele C. Mattioli,Jérémy Bouyer +8 more
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TLDR
A PCP for tsetse-transmitted animal trypanosomosis, the scourge of poor livestock keepers in tropical Africa, is outlined, with a mixed-record of success and failure in past efforts.About:
This article is published in Trends in Parasitology.The article was published on 2017-07-01 and is currently open access. It has received 84 citations till now.read more
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Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?
Philippe Büscher,Jean-Mathieu Bart,Marleen Boelaert,Bruno Bucheton,Giuliano Cecchi,Nakul Chitnis,Nakul Chitnis,David Courtin,Luisa M. Figueiredo,José-Ramon Franco,Pascal Grébaut,Epco Hasker,Hamidou Ilboudo,Vincent Jamonneau,Mathurin Koffi,Veerle Lejon,Annette MacLeod,Justin Masumu,Enock Matovu,Raffaele C. Mattioli,Harry Noyes,Albert Picado,Kat S. Rock,Brice Rotureau,Gustave Simo,Sophie Thevenon,Sandra Trindade,Philippe Truc,Nick Van Reet +28 more
TL;DR: It is argued that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.
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Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System.
Magdalena Radwanska,Nick Vereecke,Nick Vereecke,Violette Deleeuw,Joar Pinto,Stefan Magez,Stefan Magez +6 more
TL;DR: The classification and global distribution of single cell extracellular parasites, the adaptation of human infective trypanosomes that allow them to survive innate defense molecules unique to man, gorilla, and baboon serum, and the discovery of sexual reproduction of try panosomes in the tsetse vector are reviewed.
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The elimination of human African trypanosomiasis: Achievements in relation to WHO road map targets for 2020
José R. Franco,Giuliano Cecchi,Massimo Paone,Abdoulaye Diarra,Lise Grout,Augustin Kadima Ebeja,Pere P. Simarro,Weining Zhao,Daniel Argaw +8 more
TL;DR: Togo and Côte d’Ivoire were the first countries to be validated for achieving elimination of HAT as a public health problem at the national level and applications from three additional countries are under review by the World Health Organization.
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The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis.
TL;DR: The notional global target of<2,000 reported HAT cases by 2020 has already been met, and this extraordinary success story is bringing the gambiense HAT elimination programme into the realms of some of the more celebrated— and better funded—programmes.
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Development of a Nanobody-based lateral flow assay to detect active Trypanosoma congolense infections.
Joar Esteban Pinto Torres,Julie Goossens,Ding Jianzu,Zeng Li,Shaohong Lu,Didier Vertommen,Peter Naniima,Rui Chen,Serge Muyldermans,Yann G.-J. Sterckx,Stefan Magez +10 more
TL;DR: The development and evaluation of the first Nb-based antigen detection LFA to identify active T. congolense infections is presented, which can be employed to detect parasitaemia in plasma samples from experimentally infected mice and cattle and can serve as ‘test-of-cure’ tools.
References
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Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique.
Marc J. B. Vreysen,Khalfan M. Saleh,Mashavu Y. Ali,Abdulla M. Abdulla,Zeng-Rong Zhu,Kassim G. Juma,V. Arnold Dyck,Atway R. Msangi,Paul A. Mkonyi,H. Udo Feldmann +9 more
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The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases
Pere P. Simarro,Giuliano Cecchi,Massimo Paone,José R. Franco,Abdoulaye Diarra,Jose Antonio Ruiz,Eric M. Fèvre,Fabrice Courtin,Raffaele C. Mattioli,Jean Jannin +9 more
TL;DR: Although efforts are still needed to reduce the number of undetected and unreported cases, the comprehensive, village-level mapping of HAT control activities over a ten-year period ensures a detailed and reliable representation of the known geographic distribution of the disease.
Journal ArticleDOI
Estimating and Mapping the Population at Risk of Sleeping Sickness
Pere P. Simarro,Giuliano Cecchi,José R. Franco,Massimo Paone,Abdoulaye Diarra,José Antonio Ruiz-Postigo,Eric M. Fèvre,Raffaele C. Mattioli,Jean Jannin +8 more
TL;DR: The presented maps of different HAT risk levels will help to develop site-specific strategies for control and surveillance, and to monitor progress achieved by ongoing efforts aimed at the elimination of sleeping sickness.
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The animal trypanosomiases and their chemotherapy: a review.
TL;DR: This review provides a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance.
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The Effect of the Tsetse Fly on African Development
TL;DR: The authors found that ethnic groups inhabiting TseTse-suitable areas were less likely to use domesticated animals and the plow and had a lower population density, and these correlations are not found in the Tropics outside of Africa.