Journal ArticleDOI
Human African trypanosomiasis
TLDR
Since patients are also reported from non-endemic countries, human African trypanosomiasis should be considered in differential diagnosis for travellers, tourists, migrants, and expatriates who have visited or lived in endemic areas.About:
This article is published in The Lancet.The article was published on 2017-11-25. It has received 567 citations till now. The article focuses on the topics: Trypanosomiasis & African trypanosomiasis.read more
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Book ChapterDOI
The Democratic Republic of Congo
Tom De Bruyn,Johan Wets +1 more
TL;DR: The information in this chapter is based on interviews conducted in collaboration with the MIDA coordinator Sefu Kawaya during a two-week visit to Kinshasa as discussed by the authors.
Journal ArticleDOI
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
Victor Kande Betu Ku Mesu,Wilfried Mutombo Kalonji,Clélia Bardonneau,Olaf Valverde Mordt,Séverine Blesson,François Simon,Sophie Delhomme,Sonja C. Bernhard,Willy Kuziena,Jean Pierre Fina Lubaki,Steven Lumeya Vuvu,Pathou Nganzobo Ngima,Hélène Mahenzi Mbembo,Medard Ilunga,Augustin Kasongo Bonama,Josué Amici Heradi,Jean Louis Lumaliza Solomo,Guylain Mandula,Lewis Kaninda Badibabi,Francis Regongbenga Dama,Papy Kavunga Lukula,Digas Ngolo Tete,Crispin Lumbala,Bruno Scherrer,Nathalie Strub-Wourgaft,Antoine Tarral +25 more
TL;DR: The findings show that oral fexinidazole is effective and safe for the treatment of Tpanosoma brucei gambiense infection compared with nifurtimox eflornithine combination therapy in patients with late-stage g-HAT.
Journal ArticleDOI
Challenges and recent progress in drug discovery for tropical diseases
TL;DR: Some of the challenges involved in developing new drugs to treatfectious tropical diseases are discussed, and there is still a long way to go.
Journal ArticleDOI
The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases
TL;DR: This review highlights the potential that remains untapped in natural products as drug leads for NTDs, and covers natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of N TDs.
Journal ArticleDOI
Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?
Philippe Büscher,Jean-Mathieu Bart,Marleen Boelaert,Bruno Bucheton,Giuliano Cecchi,Nakul Chitnis,Nakul Chitnis,David Courtin,Luisa M. Figueiredo,José-Ramon Franco,Pascal Grébaut,Epco Hasker,Hamidou Ilboudo,Vincent Jamonneau,Mathurin Koffi,Veerle Lejon,Annette MacLeod,Justin Masumu,Enock Matovu,Raffaele C. Mattioli,Harry Noyes,Albert Picado,Kat S. Rock,Brice Rotureau,Gustave Simo,Sophie Thevenon,Sandra Trindade,Philippe Truc,Nick Van Reet +28 more
TL;DR: It is argued that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.
References
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Book
Statistical analysis of spatial point patterns
TL;DR: This book provides an introduction to statistical methods for analysing data in the form of spatial point distributions, described in intuitive terms and illustrated by many applications to real data drawn from the biological and biomedical sciences.
BookDOI
Statistical Methods in Diagnostic Medicine
TL;DR: This book discusses the design of Diagnostic Accuracy Studies, the construction of a Smooth ROC Curve, and how to select a Sampling Plan for Readers based on Sensitivity and Specificity.
Journal ArticleDOI
Human African trypanosomiasis
TL;DR: If national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible, the World Health Organization has stated.
Book ChapterDOI
The Democratic Republic of Congo
Tom De Bruyn,Johan Wets +1 more
TL;DR: The information in this chapter is based on interviews conducted in collaboration with the MIDA coordinator Sefu Kawaya during a two-week visit to Kinshasa as discussed by the authors.