Nick Van Reet

TL;DR: It is argued that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.

TL;DR: Experimental transmission experiments combined with molecular parasite detection in blood fed flies provided evidence that dermal trypanosomes can be acquired from the inoculation site immediately after the initial transmission, and intradermal parasite expansion induces elevated skin surface temperatures.

TL;DR: Monomorphic and pleomorphic recombinant Trypanosoma brucei expressing the Renilla luciferase were generated and it was shown that parasites located in the testis, as compared to those located inThe abdominal cavity, were not readily cleared by the drugs.

TL;DR: Experimental murine infections of human African trypanosomiasis caused by Trypanosoma brucei gambiense showed that these isolates could be clustered into three groups with different characteristics regarding their in vivo infection properties, immune response and capacity for brain invasion, mimicking the broad clinical diversity observed in HAT.

TL;DR: To address the limitations of the current diagnostics for equine trypanosomosis, studies into improved molecular and serological tests with the highest possible sensitivity and specificity are recommended.