Journal ArticleDOI
Developing networks play a similar melody.
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TLDR
The role of the early depolarizing action of GABA(A) and glycine receptors and the sequential expression of GABA and glutamate synapses in the formation of functional networks is discussed in this paper.About:
This article is published in Trends in Neurosciences.The article was published on 2001-06-01. It has received 612 citations till now. The article focuses on the topics: Giant depolarizing potentials & Biological neural network.read more
Citations
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Excitatory actions of gaba during development: the nature of the nurture.
TL;DR: This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
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Abnormal neural oscillations and synchrony in schizophrenia
TL;DR: Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections.
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Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus
TL;DR: The study reveals the key morphological transitions of newborn granule neurons during their course of maturation and shows that the morphological maturation is differentially affected by age and experience, as shown by comparisons between adult and postnatal brains and between housing conditions.
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
TL;DR: It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
References
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Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
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Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TL;DR: In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.
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GABA: an excitatory transmitter in early postnatal life
TL;DR: In the adult mammalian CNS, GABA is the main inhibitory transmitter, and during the early neonatal period, GABA acting on GABAA receptors provides most of the excite drive, whereas excitatory glutamatergic synapses are quiescent.
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GABAA, NMDA and AMPA receptors: a developmentally regulated `ménage à trois'
TL;DR: Determining the mechanisms underlying the development of this 'ménage à trois' will shed light not only on the wide range of trophic roles of glutamate and GABA in the developing brain, but also on the significance of the transition from neonatal to adult forms of plasticity.