Journal ArticleDOI
Development and characterization of pH-responsive polyethylene glycol-co-poly(methacrylic acid) polymeric network system for colon target delivery of oxaliplatin: Its acute oral toxicity study
TLDR
These hydrogels can become an excellent candidates for colon targeting of OXP to treat colorectal cancer with no toxicity and are confirmed as non-toxic and biocompatible for biological system.Abstract:
An oral route of administration is a most acceptable route for a patient, so we designed chemically cross-linked polyethylene glycol-co-poly(methacrylic acid) oral hydrogels (PEGMA 4000) by free radical polymerization method for pH-responsive colon target delivery of oxaliplatin (OXP) Polyethylene glycol (PEG 4000) was cross-linked chemically with methacrylic acid (MAA) in distilled water Ammonium peroxodisulfate (APS) and N, N-methylene bisacrylamide (MBA) were used as initiator and cross-linker respectively OXP was loaded in prepared hydrogels FTIR, DSC, TGA, SEM, and XRD were conducted for characterization of developed hydrogels which endorsed the formation of new polymeric network The pH-sensitive behavior of hydrogels was observed by swelling dynamics and equilibrium swelling ratio at low (12) and higher pH (74) Toxicity study was also conducted on rabbits to evaluate toxicity and biocompatibility of developed carrier system to biological system Hydrogels with higher PEG 4000 concentration showed maximum swelling and higher drug loading at 74 pH Toxicity study confirmed the developed hydrogels as non-toxic and biocompatible for biological system Resultantly, these hydrogels can become an excellent candidates for colon targeting of OXP to treat colorectal cancer with no toxicityread more
Citations
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Peptide-based stimuli-responsive biomaterials
TL;DR: In this paper, the authors explore recent advances in the design and engineering of materials wholly or principally constructed from peptides, and focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure.
Journal ArticleDOI
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application.
TL;DR: The applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications.
Journal ArticleDOI
pH-responsive smart gels of block copolymer [pluronic F127-co-poly(acrylic acid)] for controlled delivery of Ivabradine hydrochloride: its toxicological evaluation
Natasha Nasir,Mahmood Ahmad,Mahmood Ahmad,Muhammad Usman Minhas,Kashif Barkat,Muhammad Farooq Khalid +5 more
TL;DR: In this article, a pluronic F127-co-poly(acrylic acid) smart gels were fabricated by using ethylene glycol dimethacrylate (EGDMA) as cross-linker.
Journal ArticleDOI
Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier
TL;DR: In this paper, the authors used free radical polymerization to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time.
Journal ArticleDOI
Porous and highly responsive cross-linked β-cyclodextrin based nanomatrices for improvement in drug dissolution and absorption.
Syed Faisal Badshah,Naveed Akhtar,Muhammad Usman Minhas,Kifayat Ullah Khan,Samiullah Khan,Orva Abdullah,Abid Naeem +6 more
TL;DR: In this paper, the authors proposed to enhance the solubility of Chlorthalidone by developing beta-cyclodextrin cross-linked hydrophilic nanomatrices.
References
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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A simple equation for the description of solute release. III. Coupling of diffusion and relaxation
TL;DR: In this paper, a coupled diffusion/relaxation model is presented for general analysis of the release behavior of controlled release systems using a coupled diffusional and relaxation model, and the general form of this equation's exponent is related to the geometric shape of the releasing device through its aspect ratio.
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Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy
TL;DR: In this article, the authors developed novel polyvinyl alcohol (PVA)/poly(ethylene glycol) (PEG) hydrogel blends and PVA-derived organic-inorganic hybrid materials and performed nanostructural characterizations.