Journal ArticleDOI
Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TLDR
In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.About:
This article is published in Hepatology.The article was published on 2006-06-01. It has received 3183 citations till now. The article focuses on the topics: FibroTest & Liver function tests.read more
Citations
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Journal ArticleDOI
FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
Anaïs Vallet-Pichard,Anaïs Vallet-Pichard,Vincent Mallet,Vincent Mallet,Bertrand Nalpas,Bertrand Nalpas,Virginie Verkarre,Antoine Nalpas,Valérie Dhalluin-Venier,Hélène Fontaine,Hélène Fontaine,Stanislas Pol,Stanislas Pol +12 more
TL;DR: For values outside 1.45‐3.25, the FIB‐4 index is a simple, accurate, and inexpensive method for assessing liver fibrosis and proved to be concordant with FibroTest results.
Journal ArticleDOI
EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis.
TL;DR: Liver biopsy gives a snapshot and not an insight into the dynamic changes during the process of fibrogenesis, so immunohistochemical evaluation of cellular markers such as smooth muscle actin expression for hepatic stellate cell activation, cytokeratin 7 for labeling ductular proliferation or CD34 for visualization of sinusoidal endothelial capillarization can provide additional ‘‘functional’’ information.
Journal ArticleDOI
Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
Vincent Wai-Sun Wong,Julien Vergniol,Grace Lai-Hung Wong,Juliette Foucher,Henry Lik-Yuen Chan,Brigitte Le Bail,Paul Cheung-Lung Choi,Mathurin Kowo,Anthony W.H. Chan,Wassil Merrouche,Joseph J.Y. Sung,Victor de Ledinghen +11 more
TL;DR: Transient elastography is accurate in most NAFLD patients and is useful as a screening test to exclude advanced fibrosis, and liver biopsy may be considered in patients with liver stiffness of at least 7.9 kPa.
Journal ArticleDOI
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.
TL;DR: The FIB4 index is superior to 7 other non invasive markers of fibrosis in patients with NAFLD; however its performance characteristics highlight the need for even better noninvasive markers.
Journal ArticleDOI
Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
Stuart McPherson,Stuart McPherson,Timothy Hardy,E Henderson,Alastair D. Burt,Alastair D. Burt,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +9 more
TL;DR: Contrary to current dogma, this study suggests that steatosis can progress to NASH and clinically significant fibrosis.
References
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Journal ArticleDOI
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
Frank J. Palella,Kathleen M. Delaney,Anne C. Moorman,Mark O. Loveless,Jack Fuhrer,Glen A. Satten,Diane J. Aschman,Scott D. Holmberg +7 more
TL;DR: The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
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Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
TL;DR: A study was conducted to evaluate the impact of protease inhibitors on the rates of selected opportunistic processes and mortality in patients with AIDS and found similar results.
Journal ArticleDOI
Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
Journal ArticleDOI
A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
Chun-Tao Wai,Joel K. Greenson,Robert J. Fontana,John D. Kalbfleisch,Jorge A. Marrero,Hari S. Conjeevaram,Anna S.F. Lok +6 more
TL;DR: It is shown that a simple index using readily available laboratory results can identify CHC patients with significant fibrosis and cirrhosis with a high degree of accuracy and may decrease the need for staging liver biopsy specimens among patients with CHC.
Journal ArticleDOI
Sampling variability of liver fibrosis in chronic hepatitis C.
TL;DR: It is suggested that a length of at least 25 mm is necessary to evaluate fibrosis accurately with a semiquantitative score, because variability in the distribution of fibrosis within the liver is a major limitation when using more accurate methods such as automated image analysis.