Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.
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TLDR
The FIB4 index is superior to 7 other non invasive markers of fibrosis in patients with NAFLD; however its performance characteristics highlight the need for even better noninvasive markers.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2009-10-01 and is currently open access. It has received 998 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease & Hepatic fibrosis.read more
Citations
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis.
TL;DR: Liver biopsy gives a snapshot and not an insight into the dynamic changes during the process of fibrogenesis, so immunohistochemical evaluation of cellular markers such as smooth muscle actin expression for hepatic stellate cell activation, cytokeratin 7 for labeling ductular proliferation or CD34 for visualization of sinusoidal endothelial capillarization can provide additional ‘‘functional’’ information.
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Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease
TL;DR: With continued high rates of adult obesity and DM along with an aging population, NAFLD‐related liver disease and mortality will increase in the United States and strategies to slow the growth ofNAFLD cases and therapeutic options are necessary to mitigate disease burden.
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Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
Vincent Wai-Sun Wong,Julien Vergniol,Grace Lai-Hung Wong,Juliette Foucher,Henry Lik-Yuen Chan,Brigitte Le Bail,Paul Cheung-Lung Choi,Mathurin Kowo,Anthony W.H. Chan,Wassil Merrouche,Joseph J.Y. Sung,Victor de Ledinghen +11 more
TL;DR: Transient elastography is accurate in most NAFLD patients and is useful as a screening test to exclude advanced fibrosis, and liver biopsy may be considered in patients with liver stiffness of at least 7.9 kPa.
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Performance of the aspartate aminotransferase‐to‐platelet ratio index for the staging of hepatitis C‐related fibrosis: An updated meta‐analysis
Zhong-Hua Lin,Yong-Ning Xin,Quan-Jiang Dong,Qing Wang,Xiang-Jun Jiang,Shu-Hui Zhan,Ying Sun,Shi-Ying Xuan +7 more
TL;DR: The large meta‐analysis suggests that APRI can identify hepatitis C‐related fibrosis with a moderate degree of accuracy and may decrease the need for staging liver biopsy specimens among chronic hepatitis C patients.
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Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
Stuart McPherson,Stuart McPherson,Timothy Hardy,E Henderson,Alastair D. Burt,Alastair D. Burt,Christopher P. Day,Christopher P. Day,Quentin M. Anstee,Quentin M. Anstee +9 more
TL;DR: Contrary to current dogma, this study suggests that steatosis can progress to NASH and clinically significant fibrosis.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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A method of comparing the areas under receiver operating characteristic curves derived from the same cases.
TL;DR: This paper refines the statistical comparison of the areas under two ROC curves derived from the same set of patients by taking into account the correlation between the areas that is induced by the paired nature of the data.
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Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
Jeffrey D. Browning,Lidia S. Szczepaniak,Robert L. Dobbins,Pamela Nuremberg,Jay D. Horton,Jonathan Cohen,Scott M. Grundy,Helen H. Hobbs +7 more
TL;DR: The prevalence of hepatic steatosis was greater in men than women among whites, but not in blacks or Hispanics, and significant ethnic and sex differences in the prevalence may have a profound impact on susceptibility to Steatosis‐related liver disease.
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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
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The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
Paul Angulo,Jason M. Hui,Giulio Marchesini,Ellisabetta Bugianesi,Jacob George,Geoffrey C. Farrell,Felicity Enders,Sushma Saksena,Alastair D. Burt,John P. Bida,Keith D. Lindor,Schuyler O. Sanderson,Marco Lenzi,Leon A. Adams,James G. Kench,Terry M. Therneau,Christopher P. Day +16 more
TL;DR: A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.