Journal ArticleDOI
Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening
Etta D. Pisano,Constantine Gatsonis,Edward Hendrick,Martin J. Yaffe,Janet K. Baum,Suddhasatta Acharyya,Emily F. Conant,Laurie L. Fajardo,Lawrence W. Bassett,Carl J. D'Orsi,Roberta A. Jong,Murray Rebner +11 more
TLDR
Digital mammography did, however, perform significantly better than the film method in women less than 50 years of age, in those having heterogeneously dense or very dense breasts, and premenopausal or perimenopausal women.Abstract:
Previous trials, limited in many respects, have not found digital mammography to be significantly more accurate than the standard film method. A total of 42,760 asymptomatic women seen at 33 sites in the United States and Canada requested screening mammography and underwent both film and digital examinations. Two radiologists independently interpreted the film and digital mammograms. All participants either had breast biopsy within 15 months after evaluation or had a follow-up mammogram 10 months or longer after entry to the study. The results were assessed by receiver operating characteristic analysis. Both digital and film mammograms were positive in 0.5% of women. Another 2.2% had only a positive digital study, whereas 1.9% had only a positive film study. In the remaining women, approximately 95% of the total, both imaging studies were negative. Of 335 breast cancers diagnosed within 455 days after entry to the study, approximately three fourths were found within a year after evaluation. There were no substantial differences between the digital and film findings with respect to histology or stage of disease. The area under the curve was similar for the 2 studies and was not influenced by race or the risk of breast cancer. Digital mammography did, however, perform significantly better than the film method in women less than 50 years of age, in those having heterogeneously dense or very dense breasts, and premenopausal or perimenopausal women. The digital and film methods performed equally well in women age 50 years and older, those with fatty breasts or scattered fibroglandular densities, and those who were postmenopausal.read more
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Journal ArticleDOI
Mammographic Density and the Risk and Detection of Breast Cancer
Norman F. Boyd,Helen Guo,Lisa J. Martin,Limei Sun,Jennifer Stone,Eve Fishell,Roberta A. Jong,Greg Hislop,Anna M. Chiarelli,Salomon Minkin,Martin J. Yaffe +10 more
TL;DR: Extensive mammographic density is strongly associated with the risk of breast cancer detected by screening or between screening tests, and a substantial fraction of breast cancers can be attributed to this risk factor.
Journal ArticleDOI
International evaluation of an AI system for breast cancer screening.
Scott Mayer McKinney,Marcin Sieniek,Varun Godbole,Jonathan Godwin,Natasha Antropova,Hutan Ashrafian,Trevor Back,Mary Chesus,Greg C. Corrado,Ara Darzi,Mozziyar Etemadi,Florencia Garcia-Vicente,Fiona J. Gilbert,Mark D. Halling-Brown,Demis Hassabis,Sunny Jansen,Alan Karthikesalingam,Christopher Kelly,Dominic King,Joseph R. Ledsam,David S. Melnick,Hormuz Mostofi,Lily Peng,Joshua J. Reicher,Bernardino Romera-Paredes,Richard Sidebottom,Mustafa Suleyman,Daniel Tse,Kenneth C. Young,Jeffrey De Fauw,Shravya Shetty +30 more
TL;DR: A robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening and using a combination of AI and human inputs could help to improve screening efficiency.
Journal ArticleDOI
Screening for Breast Cancer: US Preventive Services Task Force Recommendation Statement
Ned Calonge,Diana B. Petitti,Thomas G. DeWitt,Allen J. Dietrich,Kimberly D. Gregory,David C. Grossman,George Isham,Michael L. LeFevre,Rosanne M. Leipzig,Lucy N. Marion,Bernadette Mazurek Melnyk,Virginia A. Moyer,Judith K. Ockene,George F. Sawaya,J. Sanford Schwartz,Timothy J Wilt,US Preventive Serv Task Force +16 more
TL;DR: The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer.
Journal ArticleDOI
Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.
Wendie A. Berg,Jeffrey D. Blume,Jean B. Cormack,Ellen B. Mendelson,Daniel Lehrer,M. Böhm-Vélez,Etta D. Pisano,Roberta A. Jong,W. Phil Evans,Marilyn J. Morton,Mary C. Mahoney,Linda Hovanessian Larsen,Richard G. Barr,Dione M. Farria,Helga S. Marques,Karan Boparai +15 more
TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.
Journal ArticleDOI
MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer
Constance D. Lehman,Constantine Gatsonis,Christiane K. Kuhl,R. Edward Hendrick,Etta D. Pisano,Lucy Hanna,Sue Peacock,Stanley F. Smazal,Daniel D. Maki,Thomas B. Julian,Elizabeth R. DePeri,David A. Bluemke,Mitchell D. Schnall +12 more
TL;DR: MRI can detect cancer in the contralateral breast that is missed by mammography and clinical examination at the time of the initial breast-cancer diagnosis, according to a study of 969 women with a recent diagnosis of unilateral breast cancer.