Journal ArticleDOI
Differential hippocampal and cortical cholinergic activation during the acquisition, retention, reversal and extinction of a spatial discrimination in an 8-arm radial maze by mice
Reads0
Chats0
TLDR
The data constitute direct experimental evidence for a differential involvement of cholinergic septohippocampal and NBM-cortical projections in learning and memory processes.About:
This article is published in Behavioural Brain Research.The article was published on 1988-10-01. It has received 79 citations till now. The article focuses on the topics: Cholinergic & Hippocampus.read more
Citations
More filters
Journal ArticleDOI
The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory.
TL;DR: It is important to consider not only the independent contributions of age‐related changes in neuromodulatory systems to cognitive decline, but also the contribution of interactions between these systems to the learning and memory deficits associated with again and AD.
Journal ArticleDOI
The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress
TL;DR: Recent attempts to understand the role of the NBM Ch neurons in higher cognitive function by the use of selective lesion analyses and electrophysiological recording techniques are focused upon.
Journal ArticleDOI
Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory
E.A Van der Zee,P.G.M. Luiten +1 more
TL;DR: A hypothesis for the role of muscarinic receptors in learning and memory in terms of modulation between learning and recall states of brain areas at the postsynaptic level is proposed by way of immunocytochemistry employing the monoclonal antibody M35.
Journal ArticleDOI
Cholinergic system and memory in the rat: effects of chronic ethanol, embryonic basal forebrain brain transplants and excitotoxic lesions of cholinergic basal forebrain projection system.
Thomas Arendt,Y. Allen,R.M. Marchbanks,Markus M. Schugens,J. Sinden,P.L. Lantos,Jeffrey A. Gray +6 more
TL;DR: The results indicate that the forebrain cholinergic system acts as a whole, without major functional differences between the projections originating in the medial septal area/diagonal band complex and the basal nucleus, and that it discharges a very general function in cognitive processes.
Journal ArticleDOI
Muscarinic cholinergic influences in memory consolidation.
TL;DR: Evidence of increases in hippocampal and cortical acetylcholine levels following learning experiences support the view that endogenous ACh release is involved in long-term memory consolidation, and the findings indicating that mR drug treatments influence plasticity in the hippocampus and in sensory cortices strongly suggest thatmR activation isinvolved in the storage of information in these brain regions.
References
More filters
Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
Alzheimer's disease: a disorder of cortical cholinergic innervation
TL;DR: Advances in neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.
Journal ArticleDOI
Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6).
TL;DR: It appears that the age-related changes of memory function as well as some of the behavioral disturbances seen in the dementia of Alzheimer's Disease may be related to pathological alterations along central cholinergic pathways.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.