Journal ArticleDOI
Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory
E.A Van der Zee,P.G.M. Luiten +1 more
TLDR
A hypothesis for the role of muscarinic receptors in learning and memory in terms of modulation between learning and recall states of brain areas at the postsynaptic level is proposed by way of immunocytochemistry employing the monoclonal antibody M35.About:
This article is published in Progress in Neurobiology.The article was published on 1999-08-01. It has received 273 citations till now. The article focuses on the topics: Muscarinic acetylcholine receptor M4 & Muscarinic acetylcholine receptor M2.read more
Citations
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Journal ArticleDOI
Cerebral microvascular pathology in aging and Alzheimer's disease.
Eszter Farkas,Paul G.M. Luiten +1 more
TL;DR: The present review focuses on the microv vascular aspects of neurodegenerative processes in aging and AD with special attention to cerebral blood flow, neural metabolic changes and the abnormalities in microvascular ultrastructure.
Journal ArticleDOI
Alzheimer's disease: Targeting the Cholinergic System
Talita H. Ferreira-Vieira,Isabella M. Guimaraes,Flavia Rodrigues da Silva,Fabiola M. Ribeiro +3 more
TL;DR: Synthesis of cholinergic neurons located in the basal forebrain, including the neurons that form the nucleus basalis of Meynert, are severely lost in Alzheimer’s disease, and drugs that act on the choline system represent a promising option to treat AD patients.
Journal ArticleDOI
The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
Inge Klinkenberg,Arjan Blokland +1 more
TL;DR: It is concluded that effects on learning and memory performance which are observed after higher doses of scopolamine are mediated by primary effects on attention and sensory/stimulus discrimination, and non-specific effects on behavior (e.g., locomotor activity, anxiety).
Journal ArticleDOI
Acetylcholine modulation of neural systems involved in learning and memory
TL;DR: The hypothesis that the magnitude of acetylcholine (ACh) release in different neural systems may regulate the relative contributions of these systems to learning is offered.
Journal ArticleDOI
Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
Valentin A. Pavlov,Mahendar Ochani,Margot Gallowitsch-Puerta,Kanta Ochani,Jared M. Huston,Christopher J. Czura,Yousef Al-Abed,Kevin J. Tracey +7 more
TL;DR: A role for central muscarinic acetylcholine receptors in the activation of the cholinergic antiinflammatory pathway is described and is of interest for the use of centrally acting mus carinic cholininic enhancers as antiinflammatory agents.
References
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Journal ArticleDOI
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TL;DR: It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
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A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
Journal ArticleDOI
Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
Journal ArticleDOI
The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.