Differential regulation of antioxidant enzymes in response to oxidants.
S. Shull,Nicholas H. Heintz,Muthu Periasamy,M. Manohar,Yvonne W. M. Janssen,Joanne P. Marsh,Brooke T. Mossman +6 more
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TLDR
The data indicate that epithelial cells of the respiratory tract respond to different oxidant insults by selective induction of certain antioxidant enzymes, and gene expression of antioxidant enzymes does not appear to be coordinately regulated in these cell types.About:
This article is published in Journal of Biological Chemistry.The article was published on 1991-12-25 and is currently open access. It has received 413 citations till now. The article focuses on the topics: Superoxide dismutase & Xanthine oxidase.read more
Citations
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Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Antioxidant enzymes and human diseases
TL;DR: The importance of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase working together in human cells against toxic reactive oxygen species, their relationship with several pathophysiologic processes and their possible therapeutic implications are described.
Journal ArticleDOI
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
TL;DR: Results indicate that mitochondrial DNA is a critical cellular target for ROS, and persistent mitochondrial DNA damage may serve as a useful biomarker for ROS-associated diseases.
Journal ArticleDOI
Lipid hydroperoxide generation, turnover, and effector action in biological systems
TL;DR: An aspect of related interest that is under intensive investigation is lipid peroxidation/LOOH-mediated stress signaling, which may evoke a variety of cellular responses, ranging from induction of antioxidant enzymes to apoptotic death.
Journal ArticleDOI
Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems.
TL;DR: A remarkable array of systems for defense; damage removal, replacement, and repair; adaptation; growth modulation; and apoptosis make it possible for us to enjoy life in an oxygen‐rich environment.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
Macrophages and polymorphonuclear neutrophils in lung defense and injury
Yves Sibille,Herbert Y. Reynolds +1 more
TL;DR: Alveolar macrophages are part of the regulatory mechanisms of PMN mobility and adherence that appears to be crucial in the initiation of some inflammatory reactions, and this supports a central role for alveolarmacrophages in the regulation of PMn traffic in the lungs.
Journal ArticleDOI
Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase
TL;DR: It was shown that at any given pH and oxygen tension, the amount of univalently reduced oxygen, which was detectable in terms of the reduction of cytochrome c, rose as the turnover rate of the enzyme was decreased by decreasing the concentration of xanthine.
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