Journal ArticleDOI
Direct atom-efficient esterification between carboxylic acids and alcohols catalyzed by amphoteric, water-tolerant TiO(acac)2.
Chien-Tien Chen,Yogesh S. Munot +1 more
TLDR
The new neutral catalytic protocol with the optimal TiO(acac)2 tolerates many stereo/electronic structural variations in both ( di)acid and (di)alcohol components with high chemoselectivity.Abstract:
A diverse array of oxometallic species were examined as catalysts for a test direct condensation of benzoic acid and 2-phenylethanol in 1:1 stoichiometry. Besides group IVB MOCl2−xH2O and TiOX2−xH2O, group VB VOCl2−xTHF and group IVB TiO(acac)2 were found to be the most efficient and water-tolerant catalysts for the test reaction. The new neutral catalytic protocol with the optimal TiO(acac)2 tolerates many stereo/electronic structural variations in both (di)acid (1°−3° alkyl and aryl) and (di)alcohol (1°, 2° alkyl, and aryl) components with high chemoselectivity.read more
Citations
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Stereoselective Synthesis of (E)-α,β-Unsaturated Esters via Carbene-Catalyzed Redox Esterification
TL;DR: Stereoselective, carbene-mediated redox esterification of alkynyl aldehydes provides mild and atom economical access to (E)-configurated, α,β-unsaturated carboxylic esters.
Journal ArticleDOI
A Metal‐Free Oxidative Esterification of the Benzyl CH Bond
TL;DR: In this article, an efficient metal-free oxidative esterification of benzyl CH bonds was developed using tetrabutylammonium iodide as catalyst and tert-butyl hydroperoxide as co-oxidant.
Journal ArticleDOI
Easy access to benzylic esters directly from alkyl benzenes under metal-free conditions.
TL;DR: An efficient metal free protocol has been developed for the synthesis of benzylic esters via a cross dehydrogenative coupling involving alkylbenzene as a self- or as a cross-coupling partner(s) via the intermediacy of Ar-COOH.
Journal ArticleDOI
Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease
TL;DR: Recent evidence suggests an important role of gut microbial dysbiosis in IBD, and this may be associated with changes in faecal volatile organic metabolites (VOMs).
Journal ArticleDOI
Highly Enantioselective Aerobic Oxidation of α-Hydroxyphosphonates Catalyzed by Chiral Vanadyl(V) Methoxides Bearing N-Salicylidene-α-aminocarboxylates
TL;DR: An unprecedented vanadyl(V) methoxide complex derived from 3,5-dibromo-N-salicylidene-l-tert-leucinate enables highly enantioselective aerobic oxidations of α-hydroxyphosphonates at ambient temperature with selectivity factors ranging from 3 to >99 as mentioned in this paper.
References
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Journal ArticleDOI
Novel template effects of distannoxane catalysts in highly efficient transesterification and esterification
Journal ArticleDOI
Direct Condensation of Carboxylic Acids with Alcohols Catalyzed by Hafnium(IV) Salts
TL;DR: It is shown that the direct condensation of equimolar amounts of carboxylic acids and alcohols can be achieved with the use of hafnium(IV) salts, such as commercially available ha fnium( IV) chloride and hafnia(IV), which may be suitable for large-scale operations.
Journal ArticleDOI
Direct ester condensation from a 1:1 mixture of carboxylic acids and alcohols catalyzed by hafnium(IV) or zirconium(IV) salts
TL;DR: In this paper, the direct condensation of equimolar amounts of carboxylic acids and alcohols could be achieved using hafnium (IV) or zirconium(IV) salts.
Journal ArticleDOI
Catalytic asymmetric coupling of 2-naphthols by chiral tridentate oxovanadium (IV) complexes.
† Sang-Wen Hon,† Chun-Hsin Li,Jen-Huang Kuo,N. B. Barhate,Yi-Hung Liu,and Yu Wang,Chien-Tien Chen +6 more
TL;DR: The best scenario involves the use of a vanadyl complex arising from 2-hydroxy-1-naphthaldehyde and valine (or phenylalanine) in CCl(4), leading to BINOLs in good yields and with enantioselectivities of up to 68%.