Journal ArticleDOI
One‐Pot Oxidative Esterification and Amidation of Aldehydes
Kekeli Ekoue-Kovi,Christian Wolf +1 more
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TLDR
Several concepts that are often complementary in substrate scope, functional group tolerance, and reaction outcome have emerged, thus providing a wide range of alternatives to classical ester and amide synthesis via carboxylic acid intermediates.Abstract:
During recent years, the direct transformation of aldehydes into esters or amides has developed into a vigorous research area and powerful one-pot oxidative esterification and amidation procedures have been reported. Several concepts that are often complementary in substrate scope, functional group tolerance, and reaction outcome have emerged, thus providing a wide range of alternatives to classical ester and amide synthesis via carboxylic acid intermediates.read more
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Rethinking amide bond synthesis
TL;DR: A new generation of amide-forming reactions are reviewed and summarize their potential application to current synthetic challenges, including the development of catalytic amide formation, the synthesis of therapeutic peptides and the preparation of modified peptide and proteins.
Journal ArticleDOI
Metal-catalysed approaches to amide bond formation
TL;DR: In this tutorial review, highlights of the recent literature have been presented covering the key areas where metal catalysts have been used in amide bond formation.
Journal ArticleDOI
Electrochemical strategies for C-H functionalization and C-N bond formation.
TL;DR: This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon-hydrogen functionalization and carbon-nitrogen bond formation strategies and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.
Journal ArticleDOI
NHC Catalyzed Oxidations of Aldehydes to Esters: Chemoselective Acylation of Alcohols in Presence of Amines
TL;DR: Not just one but two carbenes of the same structure act cooperatively in oxidative acylations of alcohols with aldehydes by using a readily available cheap organic oxidant.
Journal ArticleDOI
Metal‐Free Oxidative Carbon‐Heteroatom Bond Formation Through C–H Bond Functionalization
TL;DR: In this paper, the development of metal-free coupling methods for unactivated compounds under oxidative reaction conditions is discussed with numerous examples. And the utility of these methods in syntheses of desired products and the mechanisms of their formation are discussed.
References
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Journal ArticleDOI
Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides.
Journal ArticleDOI
Facile Conversion of Alcohols into Esters and Dihydrogen Catalyzed by New Ruthenium Complexes
TL;DR: In this paper, an efficient, environmentally benign method for the preparation of esters from alcohols under mild, neutral conditions without the need for carboxylic acid derivatives and condensing agents was developed.
Journal ArticleDOI
Organocatalyzed conjugate umpolung of α,β-unsaturated aldehydes for the synthesis of γ-butyrolactones
Christian Burstein,Frank Glorius +1 more
Journal ArticleDOI
N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: γ-Butyrolactones by Direct Annulations of Enals and Aldehydes
TL;DR: This process demonstrates an unprecedented reaction mode for the generation of nucleophilic carbanions with a multifunctional organocatalyst under exceptionally mild and convenient reaction conditions.
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