Journal ArticleDOI
Direct organo-catalytic asymmetric alpha-amination of aldehydes--a simple approach to optically active alpha-amino aldehydes, alpha-amino alcohols, and alpha-amino acids.
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This article is published in Angewandte Chemie.The article was published on 2002-05-17. It has received 385 citations till now. The article focuses on the topics: Amino acid & Amination.read more
Citations
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Journal ArticleDOI
Asymmetric enamine catalysis.
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Small-molecule H-bond donors in asymmetric catalysis.
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Asymmetric organocatalytic domino reactions.
TL;DR: This Minireview discusses the current development of domino reactions mediated by organocatalysts, as this principle is used very efficiently in the biosynthesis of complex natural products starting from simple precursors.
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Enamine-Based Organocatalysis with Proline and Diamines: The Development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels−Alder Reactions
TL;DR: The contributions of this laboratory to converting enzymatic enamines, and in some cases imines, into a versatile catalytic asymmetric strategy powered by small organic molecules are summarized.
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Asymmetric aminocatalysis--gold rush in organic chemistry.
TL;DR: This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development.
References
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Journal ArticleDOI
Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
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New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels−Alder Reaction
TL;DR: In this article, the first highly enantioselective organocatalytic Diels-Alder reaction was reported, which is the state-of-the-art for asymmetric catalysts.
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Amino Acid Catalyzed Direct Asymmetric Aldol Reactions: A Bioorganic Approach to Catalytic Asymmetric Carbon-Carbon Bond-Forming Reactions
TL;DR: Direct asymmetric catalytic aldol reactions have been successfully performed using aldehydes and unmodified ketones together with commercially available chiral cyclic secondary amines as catalysts and the observed stereochemistry of the products is in accordance with the proposed transition state.