Journal ArticleDOI
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer
Kathrin Mutze,Rupert Langer,Felix Schumacher,Karen Becker,Katja Ott,Alexander Novotny,Alexander Hapfelmeier,Heinz Höfler,Gisela Keller +8 more
TLDR
In vitro data support a functional relationship between DNMT1 and cisplatin sensitivity andDNMT1 may represent a promising target for alternative therapeutic strategies for a subset of GC patients with better outcomes following neoadjuvant chemotherapy.About:
This article is published in European Journal of Cancer.The article was published on 2011-08-01. It has received 117 citations till now. The article focuses on the topics: Cisplatin & Decitabine.read more
Citations
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Journal ArticleDOI
DNA methyltransferases: a novel target for prevention and therapy
TL;DR: Inhibition of DNMTs has demonstrated reduction in tumor formation in part through the increased expression of tumor suppressor genes, and this represents a promising approach for the prevention and treatment of many cancers.
Journal ArticleDOI
miR-200b and miR-200c as Prognostic Factors and Mediators of Gastric Cancer Cell Progression
Hailin Tang,Min Deng,Yunyun Tang,Xinhua Xie,Jiaoli Guo,Yanan Kong,Feng Ye,Qi Su,Xiaoming Xie +8 more
TL;DR: It is suggested that miR-200b and miC-200c, as valuable markers of gastric cancer prognosis, may be a promising approach to human gastriccancer treatment.
Journal ArticleDOI
Efficient Enhancement of Electrochemiluminescence from Cadmium Sulfide Quantum Dots by Glucose Oxidase Mimicking Gold Nanoparticles for Highly Sensitive Assay of Methyltransferase Activity
TL;DR: An original electrochemiluminescence (ECL) method for the detection of DNA methyltransferase (MTase) activity is presented based on the efficient enhanced ECL of CdS quantum dots (QDs) through catalytic generation of coreactant and energy transfer by glucose oxidase mimicking gold nanoparticles (Au NPs).
Journal ArticleDOI
DNA and histone methylation in gastric carcinogenesis
Danielle Queiroz Calcagno,Carolina Oliveira Gigek,Elizabeth Suchi Chen,Rommel Rodríguez Burbano,Marília de Arruda Cardoso Smith +4 more
TL;DR: Recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome are reviewed.
Journal ArticleDOI
SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer.
Erica Hlavin Bell,Arup R. Chakraborty,Xiaokui Mo,Ziyan Liu,Konstantin Shilo,Simon Kirste,Petra Stegmaier,Petra Stegmaier,Maureen McNulty,Niki Karachaliou,Rafael Rosell,Gerold Bepler,David P. Carbone,Arnab Chakravarti +13 more
TL;DR: Low expression of SMARCA4/BRG1 is significantly associated with worse prognosis; however, it is a novel significant predictive biomarker for increased sensitivity to platinum-based chemotherapy in NSCLC.
References
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Journal ArticleDOI
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Ting-Chao Chou,Paul Talalay +1 more
TL;DR: A generalized method for analyzing the effects of multiple drugs and for determining summation, synergism and antagonism has been proposed and has been used to analyze experimental data obtained from enzymatic, cellular and animal systems.
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Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
David Cunningham,William H. Allum,Sally P. Stenning,Jeremy Thompson,Marianne Nicolson,J. Howard Scarffe,F. Lofts,Stephen Falk,Timothy Iveson,David Smith,Ruth E Langley,Monica Verma,Simon Weeden,Yu Jo Chua +13 more
TL;DR: In patients with operable gastric or lower esophageal adenocarcinomas, a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.
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Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
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Epigenetics in Cancer
TL;DR: This account of epigenetics in cancer reviews the mechanisms and consequences of epigenetic changes in cancer cells and concludes with the implications of these changes for the diagnosis, prognosis, and treatment of cancer.
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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Ina Rhee,Kurtis E. Bachman,Ben Ho Park,Kam Wing Jair,Ray Whay Chiu Yen,Kornel E. Schuebel,Hengmi Cui,Andrew P. Feinberg,Christoph Lengauer,Kenneth W. Kinzler,Stephen B. Baylin,Bert Vogelstein +11 more
TL;DR: It is demonstrated that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and compelling evidence that such methylation is essential for optimal neoplastic proliferation is provided.