Patent
DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
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In this paper, isolated DNA sequences, expression vectors and transformant cells are provided which allow for the large scale production of vascular endothelial cell growth factor, which is useful in the treatment of wound in which neovascularization or reendothelialization is required for healing.Abstract:
Isolated DNA sequences, expression vectors and transformant cells are provided which allow for the large scale production of vascular endothelial cell growth factor. The vascular endothelial cell growth factor is useful in the treatment of wounds in which neovascularization or reendothelialization is required for healing.read more
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TL;DR: In this paper, the authors used human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and variants, for the treatment of age-related macular degeneration, as well as other diseases and disorders characterized by undesirable or excessive neovascularization.
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Production of vascular endothelial cell growth factor and dna encoding same
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References
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Process for amplifying nucleic acid sequences
TL;DR: In this article, a process for amplifying any desired specific nucleic acid sequence contained in a mixture of nucleic acids or mixture thereof is described, which can be repeated as often as desired.
Patent
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
Kary Banks Mullis,Norman Arnheim,Randall K. Saiki,Henry A. Erlich,Glenn Thomas Horn,Stephen J. Scharf +5 more
TL;DR: In this paper, the authors proposed a method for synthesizing nucleic acid sequences using primers, which can be repeated stepwise or simultaneously and can be replicated as often as desired.
PatentDOI
Human vascular permeability factor.
TL;DR: A cDNA having a base sequence for human vascular permeability factor has been cloned and characterized and the amino acid sequence of the human vascular protein has been determined as discussed by the authors, which is the first cDNA with a base-sequence for VF.
Patent
Vascular permeability factor
TL;DR: A purified vascular permeability protein factor and method of manufacture is described in this article, where the factor has the following characteristics: a) in an aqueous solution (.01M Na3PO4, pH 7) whose concentration of NaCl is varied linearly, the factor is eluted from a heparin-separharose chromatography column in a peak centered at 0.4M NaCl, and b) when subjected to SDS gel electrophoresis in a 7.5 % polyacrylamide slab gel (0.375M tris
Patent
cDNA AND GENE FOR HUMAN ANGIOGENIN (ANGIOGENESIS FACTOR) AND METHODS OF EXPRESSION.
Bert L. Vallee,Kotoku Kurachi +1 more
TL;DR: In this article, DNA sequences encoding a protein having angiogenic activity are introduced into host cells and direct the production of the protein, which is useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes.
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